ArticleEvidence-based complementary and alternative medicine : eCAM2015
Acupuncture for Frequent Migraine: A Randomized, Patient/Assessor Blinded, Controlled Trial with One-Year Follow-Up.
Article in Evidence-based complementary and alternative medicine : eCAM, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02592681 (Comparison of the Prophylactic Effect Between Acupuncture and Acupressure on Menstrual Migraine), which is not on this map. Cited by 31 papers, 11 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Comparison of the Prophylactic Effect Between Acupuncture and Acupressure on Menstrual Migraine
Who cites it
31 citing papers in PubMed, 11 syntheses or guidelines pooled it.
- Effectiveness of neuromodulation techniques for migraine prophylaxis: a systematic review and network meta-analysis of randomized controlled trials.BMC complementary medicine and therapies · 2026Pooled it
- Acupuncture improves migraine and quality of life in patients with migraine: a systematic review with meta-analysis.Systematic reviews · 2025Pooled it
- Does the outcome of acupuncture differ according to the location of sham needling points in acupuncture trials for migraine? A systematic review and network meta-analysis.Frontiers of medicine · 2025Pooled it
- The use of acupuncture for addressing neurological and neuropsychiatric symptoms in patients with long COVID: a systematic review and meta-analysis.Frontiers in neurology · 2024Pooled it
- The durable effect of acupuncture for episodic migraine: a systematic review and meta-analysis.Frontiers in neuroscience · 2023Pooled it
- Efficacy and Safety of Oral Chinese Herbal Medicine for Migraine: A Systematic Review and Meta-Analyses Using Robust Variance Estimation Model.Frontiers in neurology · 2022Pooled it
- Comparative efficacy of acupuncture-related therapy for migraine: A systematic review and network meta-analysis.Frontiers in neurology · 2022Pooled it
- Efficacy of acupuncture for migraine prophylaxis: a trial sequential meta-analysis.Journal of neurology · 2021Pooled it
- Acupuncture versus propranolol in migraine prophylaxis: an indirect treatment comparison meta-analysis.Journal of neurology · 2020Pooled it
- Acupuncture for Chronic Pain: Update of an Individual Patient Data Meta-Analysis.The journal of pain · 2018Pooled it
- Acupuncture for the prevention of episodic migraine.The Cochrane database of systematic reviews · 2016Pooled it
- Manual acupuncture versus sham acupuncture and usual care for prophylaxis of episodic migraine without aura: multicentre, randomised clinical trial.BMJ (Clinical research ed.) · 2020Trial
- Acupuncture modulates the abnormal brainstem activity in migraine without aura patients.NeuroImage. Clinical · 2017Trial
- Comparative Efficacy of Acupuncture, Pharmacological Interventions, Sham Acupuncture, and Placebo for Migraine Prevention: A Bayesian Network Meta-Analysis.Pain research & management · 2026Article
- Differential placebo effect of sham acupuncture for chronic pain: a network meta-analysis of randomized controlled trials.BMC complementary medicine and therapies · 2025Article
- Modulation of temporal and occipital cortex by acupuncture in non-menstrual MWoA patients: a rest BOLD fMRI study.BMC complementary medicine and therapies · 2024Article
- Article
- Bibliometric Analysis of 100 Most Highly Cited Publications on Acupuncture for Migraine.Journal of pain research · 2023Article
- Acupuncture as an acceptable option for the treatment of the sleep-pain cycle.Sleep & breathing = Schlaf & Atmung · 2022Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objectives. This study aimed to evaluate the efficacy and safety of manual acupuncture as a prophylaxis for frequent migraine. Methods. Fifty frequent migraineurs were randomly allocated to receive 16 sessions of either real acupuncture (RA = 26) or sham acupuncture (SA = 24) during 20 weeks. The primary outcomes were days with migraine over four weeks, duration, and intensity of migraine and the number of responders with more than 50% reduction of migraine days. The secondary outcomes were the relief medication, quality of migraine, quality of life, and pressure pain thresholds. Results. The two groups were comparable at baseline. At the end of the treatment, when compared with the SA group, the RA group reported significant less migraine days (RA: 5.2 ± 5.0; SA: 10.1 ± 7.1; P = 0.008), less severe migraine (RA: 2.18 ± 1.05; SA: 2.93 ± 0.61; P = 0.004), more responders (RA: 19 versus SA: 7), and increased pressure pain thresholds. No other group difference was found. Group differences were maintained at the end of the three-month follow-up, but not at the one-year follow-up. No severe adverse event was reported. Blinding was successful. Discussion. Manual acupuncture was an effective and safe treatment for short-term relief of frequent migraine in adults. Larger trials are warranted.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.