Evidence map›Paper›PMID 26060478›Full record

ArticleAfrican health sciences2014

Correlation between the cystathionine-γ-lyase (CES) and the severity of peptic ulcer disease.

Xiong Chen, Ying-Chun Wan, Tao Guo, Can-Xia Xu, Fen Wang

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in African health sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Xiong ChenDepartment of Gastroenterology, The Third Xiangya Hospital, Changsha 410013, Central South University, China.
Ying-Chun WanDepartment of Gastroenterology, The Third Xiangya Hospital, Changsha 410013, Central South University, China.
Tao GuoDepartment of Gastroenterology, The Second Xiangya Hospital, Changsha 410013, Central South University, China.
Can-Xia XuDepartment of Gastroenterology, The Third Xiangya Hospital, Changsha 410013, Central South University, China.
Fen WangDepartment of Gastroenterology, The Third Xiangya Hospital, Changsha 410013, Central South University, China.
Central South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe infection of Helicobacter pylori (H. pylori) is one of the most important causes of gastric ulcer disease. The role of hydrogen sulfide (H2S) production in H. pylori-induced gastric ulcer disease.

aimThe expression of cystathionine-γ-lyase (CSE) was determined, and correlated with the severity of gastric ulcer disease.

methodsOne hundred and eight patients were selected based on the determination of gastric ulcer and the infection of Helicobacter pylori (H. pylori), including 36 normal control, 36 patients with H. Pylori-negative gastric ulcer, and 36 patients with H. Pylori-positive gastric ulcer. RT-PCR determination was performed to determine the expression of CSE, NF-κB and IL-8.

resultsThe expression of CSE, NF-κB and IL-8 was higher in the gastric ulcer group than control group (p<0.05). Compared with the H. pylori-negative gastric ulcer, the expression of CSE, NF-κB and IL-8 was higher than H. pylori-positive gastric ulcer group (p<0.05). For H. pylori-negative gastric ulcer group, the expression of CSE positively correlated with the expression of NF-κB (r=0.98, p<0.05) and IL-8 (r=0.95, p<0.05). For H. pylori-positive gastric ulcer group, the expression of CSE also positively correlated with the expression of NF-κB (r=0.99, p<0.05) and IL-8 (r=0.85, p<0.05).

conclusionThe expression of CSE was positively correlated with the severity of gastric ulcer.

Indexed as

AdultCase-Control StudiesCystathionine gamma-LyaseFemaleHelicobacter InfectionsHelicobacter pyloriHumansHydrogen SulfideInterleukin-8MaleMiddle AgedNF-kappa BPeptic UlcerReverse Transcriptase Polymerase Chain ReactionRNA, MessengerSeverity of Illness IndexCystathionine gamma-LyaseHydrogen SulfideInterleukin-8NF-kappa BRNA, Messengercystathionine-γ-lyase (CSE)gastric ulcerHelicobacter pylorihydrogen sulfide (H2S)

Identifiers

PMID26060478
PMCPMC4449073
OpenAlexW2076177636

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.