Evidence map›Paper›PMID 26060262›Full record

ArticleInternational journal of psychiatry in medicine2015

Associations between comorbid anxiety, diabetes control, and overall medical burden in patients with serious mental illness and diabetes.

Laura A Bajor, Douglas Gunzler, Douglas Einstadter, Charles Thomas, Richard McCormick, Adam T Perzynski, Stephanie W Kanuch, Kristin A Cassidy, Neal V Dawson, Martha Sajatovic

Abstract read
In one paragraph

Article in International journal of psychiatry in medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 28 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Review
  5. The Interconnected Complexity of Diabetes and Depression.Diabetes spectrum : a publication of the American Diabetes Association · 2025
    Article
  6. Article
  7. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Laura A BajorVA Boston Healthcare Center, USA Harvard Medical School, USA laura_bajor@hms.harvard.edu.
Douglas GunzlerCenter for Health Care Research and Policy, Case Western Reserve University, MetroHealth Medical Center, USA.
Douglas EinstadterCenter for Health Care Research and Policy, Case Western Reserve University, MetroHealth Medical Center, USA.
Charles ThomasCenter for Health Care Research and Policy, Case Western Reserve University, MetroHealth Medical Center, USA.
Richard McCormickCenter for Health Care Research and Policy, Case Western Reserve University, MetroHealth Medical Center, USA.
Adam T PerzynskiCenter for Health Care Research and Policy, Case Western Reserve University, MetroHealth Medical Center, USA.
Stephanie W KanuchCenter for Health Care Research and Policy, Case Western Reserve University, MetroHealth Medical Center, USA.
Kristin A CassidySchool of Medicine, Case Western Reserve University, University Hospitals Case Medical Center, USA.
Neal V DawsonCenter for Health Care Research and Policy, Case Western Reserve University, MetroHealth Medical Center, USA.
Martha SajatovicNeurological and Behavioral Outcomes Center, University Hospitals Case Medical Center, USA.
Case Western Reserve University · USMetroHealth Medical Center · USUniversity Hospitals Case Medical Center · USVA Boston Healthcare System · US

Funding

CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR024989 · NCRR · CASE WESTERN RESERVE UNIVERSITY · PI DAVIS, PAMELA B · 2007 to 2011
$53.7M
Clinical and Translational Science Collaborative of ClevelandUL1TR000439 · NCATS · CASE WESTERN RESERVE UNIVERSITY · PI KONSTAN, MICHAEL W. · 2012 to 2016
$50.0M
Clinical and Translational Science Collaborative of ClevelandKL2TR000440 · NCATS · CASE WESTERN RESERVE UNIVERSITY · PI KONSTAN, MICHAEL W. · 2012 to 2016
$11.1M
Improving Outcomes for Individuals with Serious Mental Illness and DiabetesR01MH085665 · NIMH · CASE WESTERN RESERVE UNIVERSITY · PI DAWSON, NEAL V, SAJATOVIC, MARTHA X · 2011 to 2015
$2.9M
NCATS NIH HHS KL2 TR000440NCATS NIH HHS UL1 TR000439NCRR NIH HHS UL1 RR024989NCRR NIH HHS UL1RR024989NIMH NIH HHS 1R01MH085665NIMH NIH HHS R01 MH085665
6 · The paper itself

Abstract

objectiveWhile previous work has demonstrated elevation of both comorbid anxiety disorders and diabetes mellitus type II in individuals with serious mental illness, little is known regarding the impact of comorbid anxiety on diabetes mellitus type II outcomes in serious mental illness populations. We analyzed baseline data from patients with serious mental illness and diabetes mellitus type II to examine relationships between comorbid anxiety, glucose control as measured by hemoglobin A1c score, and overall illness burden.

methodsUsing baseline data from an ongoing prospective treatment study involving 157 individuals with serious mental illness and diabetes mellitus type II, we compared individuals with and without a comorbid anxiety disorder and compared hemoglobin A1c levels between these groups to assess the relationship between anxiety and management of diabetes mellitus type II. We conducted a similar analysis using cumulative number of anxiety diagnoses as a proxy for anxiety load. Finally, we searched for associations between anxiety and overall medical illness burden as measured by Charlson score.

resultsAnxiety disorders were seen in 33.1% (N=52) of individuals with serious mental illness and diabetes mellitus type II and were associated with increased severity of depressive symptoms and decreased function. Hemoglobin A1c levels were not significantly different in those with or without anxiety, and having multiple anxiety disorders was not associated with differences in diabetes mellitus type II control. However, depressive symptoms were significantly associated with higher hemoglobin A1c levels. Neither comorbid anxiety nor anxiety load was significantly associated with overall medical burden.

conclusionOne in three people with serious mental illness and diabetes mellitus type II had anxiety. Depressive symptoms were significantly associated with Hb1Ac levels while anxiety symptoms had no relation to hemoglobin A1c; this is consistent with previously published work. More studies are needed to better understand the relationship between depression, anxiety, and health management in people with serious mental illness and diabetes mellitus type II.

Indexed as

AdultAgedAnxiety DisordersComorbidityCost of IllnessDiabetes Mellitus, Type 2FemaleGlycated HemoglobinHumansMaleMental DisordersMiddle AgedGlycated Hemoglobinanxietybipolar disordercomorbiditydiabetes mellitusschizophreniaSerious mental illness

Identifiers

PMID26060262
PMCPMC4698974
OpenAlexW2253308244

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.