ReviewBest practice & research. Clinical gastroenterology2015
Innate immunity: actuating the gears of celiac disease pathogenesis.
Review in Best practice & research. Clinical gastroenterology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 68 citations in OpenAlex.
- m6A RNA methylation modulates antiviral response in celiac disease.Genes and immunity · 2026Article
- Innate immune dysregulation in celiac disease and refractory celiac disease: mechanisms, management and emerging therapies.Frontiers in immunology · 2026Review
- Intraepithelial Lymphocytes and LAIR1 Expression in Celiac Disease.Biomedicines · 2025Article
- Beyond the Grain: Navigating the Intersection of Gluten-Free Diets, Celiac Disease, and Cardiovascular Health.Cureus · 2024Review
- Characterisation of T cell receptor repertoires in coeliac disease.Journal of clinical pathology · 2024Article
- LncRNA ARGI Contributes to Virus-Induced Pancreatic β Cell Inflammation Through Transcriptional Activation of IFN-Stimulated Genes.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Article
- Review
- Gluten-induced RNA methylation changes regulate intestinal inflammation via allele-specificGut · 2022Article
- Microbiome signatures of progression toward celiac disease onset in at-risk children in a longitudinal prospective cohort study.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Thromboembolic complications and cardiovascular events associated with celiac disease.Irish journal of medical science · 2021Review
- From Polyclonal Sera to Recombinant Antibodies: A Review of Immunological Detection of Gluten in Foodstuff.Foods (Basel, Switzerland) · 2020Review
- Gut microbiota in Celiac Disease: microbes, metabolites, pathways and therapeutics.Expert review of clinical immunology · 2020Review
- Coeliac Disease Pathogenesis: The Uncertainties of a Well-Known Immune Mediated Disorder.Frontiers in immunology · 2020Review
- Celiac Disease and Non-celiac Wheat Sensitivity: State of Art of Non-dietary Therapies.Frontiers in nutrition · 2020Review
- The Two Faces of Wheat.Frontiers in nutrition · 2020Review
- The Gluten-Free Diet: Use in Digestive Disease Management.Current treatment options in gastroenterology · 2019Review
- Regional Diversity of the Gastrointestinal Microbiome.Cell host & microbe · 2019Review
- Celiac disease: should we care about microbes?American journal of physiology. Gastrointestinal and liver physiology · 2019Review
- Celiac disease: a comprehensive current review.BMC medicine · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Celiac disease is a T cell mediated immune disorder characterized by the loss of oral tolerance to dietary gluten and the licensing of intraepithelial lymphocytes to kill intestinal epithelial cells, leading to villous atrophy. Innate immunity plays a critical role in both of these processes and cytokines such as interleukin-15 and interferon-α can modulate innate processes such as polarization of dendritic cells as well as intraepithelial lymphocyte function. These cytokines can be modulated by host microbiota, which can also influence dendritic cell function and intraepithelial lymphocyte homeostasis. We will elaborate on the role of interleukin-15, interferon-α, and the microbiota in modulating the processes that lead to loss of tolerance to gluten and tissue destruction in celiac disease.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.