Evidence map›Paper›PMID 26060066›Full record

ArticleEuropean radiology2016

MR elastography of the liver at 3.0 T in diagnosing liver fibrosis grades; preliminary clinical experience.

Kengo Yoshimitsu, Toshimichi Mitsufuji, Yoshinobu Shinagawa, Ritsuko Fujimitsu, Ayako Morita, Hiroshi Urakawa, Hiroyuki Hayashi, Koichi Takano

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In one paragraph

Article in European radiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  12. Development of three-dimensional integral-type reconstruction formula for magnetic resonance elastography.International journal of computer assisted radiology and surgery · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Kengo YoshimitsuDepartment of Radiology, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka, 801-1011, Japan. kengo@fukuoka-u.ac.jp.
Toshimichi MitsufujiDepartment of Radiology, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka, 801-1011, Japan.
Yoshinobu ShinagawaDepartment of Radiology, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka, 801-1011, Japan.
Ritsuko FujimitsuDepartment of Radiology, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka, 801-1011, Japan.
Ayako MoritaDepartment of Radiology, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka, 801-1011, Japan.
Hiroshi UrakawaDepartment of Radiology, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka, 801-1011, Japan.
Hiroyuki HayashiDepartment of Pathology, Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka, 801-1011, Japan.
Koichi TakanoDepartment of Radiology, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka, 801-1011, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo clarify the usefulness of 3.0-T MR elastography (MRE) in diagnosing the histological grades of liver fibrosis using preliminary clinical data. MATERIALS AND

methodsBetween November 2012 and March 2014, MRE was applied to all patients who underwent liver MR study at a 3.0-T clinical unit. Among them, those who had pathological evaluation of liver tissue within 3 months from MR examinations were retrospectively recruited, and the liver stiffness measured by MRE was correlated with histological results. Institutional review board approved this study, waiving informed consent.

resultsThere were 70 patients who met the inclusion criteria. Liver stiffness showed significant correlation with the pathological grades of liver fibrosis (rho = 0.89, p < 0.0001, Spearman's rank correlation). Areas under the receiver operating characteristic curve were 0.93, 0.95, 0.99 and 0.95 for fibrosis score greater than or equal to F1, F2, F3 and F4, with cut-off values of 3.13, 3.85, 4.28 and 5.38 kPa, respectively. Multivariate analysis suggested that grades of necroinflammation also affected liver stiffness, but to a significantly lesser degree as compared to fibrosis.

conclusions3.0-T clinical MRE was suggested to be sufficiently useful in assessing the grades of liver fibrosis. KEY POINTS: MR elastography may help clinicians assess patients with chronic liver diseases. Usefulness of 3.0-T MR elastography has rarely been reported. Measured liver stiffness correlated well with the histological grades of liver fibrosis. Measured liver stiffness was also affected by necroinflammation, but to a lesser degree. 3.0-T MRE could be a non-invasive alternative to liver biopsy.

Indexed as

AdultAgedAged, 80 and overArea Under CurveBiopsy, NeedleEcho-Planar ImagingElasticityElasticity Imaging TechniquesFemaleHepatitis B, ChronicHepatitis C, ChronicHumansLiverLiver CirrhosisMaleMiddle Aged3.0 TChronic liver diseaseFibrosisMR elastographyNecroinflammation

Identifiers

PMID26060066

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.