ReviewRheumatology international2015
Platelet and red blood cell interactions and their role in rheumatoid arthritis.
Review in Rheumatology international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 47 citations in OpenAlex.
- Causal Interplay Between Platelet Indices and Rheumatoid Arthritis: Genetic Evidence From Bidirectional Mendelian Randomization.International journal of genomics · 2026Article
- Discrimination of Rheumatoid and Psoriatic Arthritis Based on Raman and NIR Spectra Using Machine-Learning Algorithms.Molecules (Basel, Switzerland) · 2025Article
- The Impact of Mechanical Circulatory Support Devices on White Blood Cell Phenotype and Function.Cardiovascular engineering and technology · 2025Review
- Red Blood Cell-Related Parameters in Rheumatoid Arthritis: Clinical Value and Immunological Significance.Journal of inflammation research · 2024Review
- The Value of Peripheral Blood Cell Ratios in Primary Membranous Nephropathy: A Single Center Retrospective Study.Journal of inflammation research · 2023Article
- Anti-Eryptotic Activity of Food-Derived Phytochemicals and Natural Compounds.International journal of molecular sciences · 2022Review
- Association Between Blood PLT and RBC Related Indices and Disease Activity in Patients with Rheumatoid Arthritis.International journal of general medicine · 2022Article
- Prediction of New Risk Genes and Potential Drugs for Rheumatoid Arthritis from Multiomics Data.Computational and mathematical methods in medicine · 2022Article
- Metabolic Influences Modulating Erythrocyte Deformability and Eryptosis.Metabolites · 2021Review
- Role of Hepcidin in Anemia of Chronic Disease in Rheumatoid Arthritis.Journal of laboratory physicians · 2021Article
- Variation of red blood cell parameters in Behcet's disease: association with disease severity and vascular involvement.Clinical rheumatology · 2021Article
- Insights in the Role of Lipids, Oxidative Stress and Inflammation in Rheumatoid Arthritis Unveiled by New Trends in Lipidomic Investigations.Antioxidants (Basel, Switzerland) · 2021Review
- Accelerated Spatial Fibrin Growth and Impaired Contraction of Blood Clots in Patients with Rheumatoid Arthritis.International journal of molecular sciences · 2020Article
- Red cell distribution width and neutrophil-lymphocyte ratio in rheumatoid arthritis.Rheumatology international · 2020Observational
- High-throughput phenotyping reveals expansive genetic and structural underpinnings of immune variation.Nature immunology · 2020Article
- The Platelet-to-Lymphocyte Ratio as an Inflammatory Marker in Rheumatic Diseases.Annals of laboratory medicine · 2019Review
- Platelets: emerging facilitators of cellular crosstalk in rheumatoid arthritis.Nature reviews. Rheumatology · 2019Review
- Red Cell Distribution Width and Platelet Count as Biomarkers of Pulmonary Arterial Hypertension in Patients with Connective Tissue Disorders.Disease markers · 2019Observational
- Tetrandrine alleviates symptoms of rheumatoid arthritis in rats by regulating the expression of cyclooxygenase-2 and inflammatory factors.Experimental and therapeutic medicine · 2018Article
- New inflammatory markers in early rheumatoid arthritis.Zeitschrift fur Rheumatologie · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cytokines, lymphocytes, platelets and several biomolecules have long been implicated in the pathology of rheumatoid arthritis (RA), and the influences of antibody production and tagging, and cytokine, chemokine and enzyme production at specific rheumatoid joints were thought to be exclusive to the advancement of disease parameters. Another role player in RA is red blood cells (RBCs) which, of late, have been found to be involved in RA pathobiology, as there is a positive correlation between RBC counts and joint pathology, as well as with inflammatory biomarkers in the disease. There is also an association between RBC distribution width and the incidence of myocardial infarction amongst RA patients, and there is a change in the lipid distribution within RBC membranes. Of late, certain RBC-associated factors with previously obscure roles and cell-derived particles thought to be inconsequential to the other constituents of plasma were found to be active biomolecular players. Several of these have been discovered to be present in or originating from RBCs. Their influences have been shown to involve in membrane dynamics that cause structural and functional changes in both platelets and RBCs. RBC-derived microparticles are emerging entities found to play direct roles in immunomodulation via interactions with other plasma cells. These correlations highlight the direct influences of RBCs on exacerbating RA pathology. This review will attempt to shed more light on how RBCs, in the true inflammatory milieu of RA, are playing an even greater role than previously assumed.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.