Evidence map›Paper›PMID 26059817›Full record

ReviewJournal of cellular physiology2016

C-ing the Genome: A Compendium of Chromosome Conformation Capture Methods to Study Higher-Order Chromatin Organization.

A Rasim Barutcu, Andrew J Fritz, Sayyed K Zaidi, André J van Wijnen, Jane B Lian, Janet L Stein, Jeffrey A Nickerson, Anthony N Imbalzano, Gary S Stein

Open access · greenAbstract readReview
In one paragraph

Review in Journal of cellular physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 59 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. The macro and micro of chromosome conformation capture.Wiley interdisciplinary reviews. Developmental biology · 2021
    Review
  10. Review
  11. Review
  12. Review
  13. Review
  14. Article
  15. Coolpup.py: versatile pile-up analysis of Hi-C data.Bioinformatics (Oxford, England) · 2020
    Article
  16. Review
  17. Article
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

A Rasim BarutcuDepartment of Cell and Developmental Biology, University of Massachusetts Medical School, Worcester, Massachusetts.
Andrew J FritzDepartment of Biochemistry, University of Vermont College of Medicine, Burlington, Vermont.
Sayyed K ZaidiDepartment of Biochemistry, University of Vermont College of Medicine, Burlington, Vermont.
André J van WijnenDepartments of Orthopedic Surgery and Biochemistry & Molecular Biology, Mayo Clinic, Rochester, Massachusetts.
Jane B LianDepartment of Biochemistry, University of Vermont College of Medicine, Burlington, Vermont.
Janet L SteinDepartment of Biochemistry, University of Vermont College of Medicine, Burlington, Vermont.
Jeffrey A NickersonDepartment of Cell and Developmental Biology, University of Massachusetts Medical School, Worcester, Massachusetts.
Anthony N ImbalzanoDepartment of Cell and Developmental Biology, University of Massachusetts Medical School, Worcester, Massachusetts.
Gary S SteinDepartment of Biochemistry, University of Vermont College of Medicine, Burlington, Vermont.
University of Vermont · USUniversity of Massachusetts Chan Medical School · USMayo Clinic · US

Funding

SUBNUCLEAR TARGETING OF TRANSCRIPTION FACTORSP01CA082834 · NCI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI STEIN, GARY S. · 2001 to 2015
$18.4M
CONTROL OF OSTEOBLAST PROLIFERATION AND DIFFERENTIATIONR01AR039588 · NIAMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI LIAN, JANE B., STEIN, GARY S. · 1990 to 2019
$8.0M
Synthesis of Osteocalcin in BoneR37DE012528 · NIDCR · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI LIAN, JANE B. · 2008 to 2017
$5.0M
Cell Cycle Regulation of Histone Gene ExpressionR01CA139322 · NCI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI STEIN, GARY S. · 2009 to 2013
$1.6M
NCI NIH HHS P01 CA082834NCI NIH HHS R01 CA139322NIAMS NIH HHS R01 AR039588NIDCR NIH HHS R37 DE012528
6 · The paper itself

Abstract

Three-dimensional organization of the chromatin has important roles in transcription, replication, DNA repair, and pathologic events such as translocations. There are two fundamental ways to study higher-order chromatin organization: microscopic and molecular approaches. In this review, we briefly introduce the molecular approaches, focusing on chromosome conformation capture or "3C" technology and its derivatives, which can be used to probe chromatin folding at resolutions beyond that provided by microscopy techniques. We further discuss the different types of data generated by the 3C-based methods and how they can be used to answer distinct biological questions.

Indexed as

MicroscopyAnimalsChromatinDNADNA RepairDNA ReplicationGenomeHumansChromatinDNA

Identifiers

PMID26059817
PMCPMC4586368
OpenAlexW2113494828

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.