ReviewFuture microbiology2015
Histoplasma capsulatum, lung infection and immunity.
Review in Future microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
58 citing papers in PubMed.
- Article
- Beyond the Usual Suspects: Gastrointestinal Histoplasmosis as a Marker of Undiagnosed Common Variable Immunodeficiency.ACG case reports journal · 2026Article
- Hidden Histoplasmosis: Adrenal and Central Nervous System Mycosis in an Immunocompetent Patient.Cureus · 2025Article
- Usefulness of Serum as a Non-Invasive Sample for the Detection ofJournal of fungi (Basel, Switzerland) · 2025Article
- Application of Principal Component Analysis as a Prediction Model for Feline Sporotrichosis.Veterinary sciences · 2025Article
- Fungus in the Fur: An Overview of Fungal Infections in Cats, Dogs, and Exotic Small Mammals.Current topics in microbiology and immunology · 2025Review
- Fungal primary and opportunistic pathogens: an ecological perspective.FEMS microbiology reviews · 2024Review
- Design of a Multi-Epitope Vaccine againstJournal of fungi (Basel, Switzerland) · 2024Article
- Antifungal Activity of Chitosan againstJournal of fungi (Basel, Switzerland) · 2023Article
- Closing the Gap in Proteomic Identification ofJournal of fungi (Basel, Switzerland) · 2023Review
- Edematous pink plaque in a patient on immunosuppression.JAAD case reports · 2023Article
- Article
- The relevance of clinical and epidemiological correlation in the early diagnosis of histoplasmosis: report of two clinical cases in Popayán, ColombiaBiomedica : revista del Instituto Nacional de Salud · 2023Review
- Steroid-Responsive Pulmonary Hypertension in a Pediatric Patient with Chronic Granulomatous Disease and Histoplasmosis.Journal of clinical immunology · 2023Article
- Central Nervous System Histoplasmosis: An Updated Insight.Pathogens (Basel, Switzerland) · 2023Article
- Endemic mycoses in children in North America: a review of radiologic findings.Pediatric radiology · 2023Review
- Headaches in a Horseback Rider.Open forum infectious diseases · 2023Article
- Article
- Antifungal Encapsulated into Ligand-Functionalized Nanoparticles with High Specificity for Macrophages.Pharmaceutics · 2022Article
- Genome-scale CRISPR screening reveals that C3aR signaling is critical for rapid capture of fungi by macrophages.PLoS pathogens · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Histoplasma capsulatum, an environmental fungus, is the most common endemic pulmonary mycosis in the USA. Disease is most frequently observed in immunocompromised patients living in endemic areas. We present the mechanisms of fungal recognition, innate immune response and adaptive immune response that lead to protection or exacerbation of disease. Current understanding of these mechanisms is the result of a continuing dialogue between clinical observations and murine studies. Mice are a powerful model to study the immune response to H. capsulatum alone or in the presence of immunomodulatory drugs. Vigilance for histoplasmosis should be exercised with novel immunosuppressive agents that target the important immune pathways identified here.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.