Evidence map›Paper›PMID 26059561›Full record

ArticleEuropean journal of trauma and emergency surgery : official publication of the European Trauma Society2016

Neutrophil-to-lymphocyte ratio as a diagnostic biomarker for the diagnosis of acute mesenteric ischemia.

R Aktimur, S Cetinkunar, K Yildirim, S H Aktimur, M Ugurlucan, N Ozlem

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Article in European journal of trauma and emergency surgery : official publication of the European Trauma Society, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
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  3. Pooled it
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  13. The importance of predictive markers in incarcerated abdominal wall hernia.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2024
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  15. Article
  16. Review
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  19. The role of neutrophil-to-lymphocyte ratio in predicting disease progression and emergency surgery indication in benign intestinal obstructions.Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES · 2022
    Article
  20. The Association of Coloproctology of Great Britain and Ireland consensus guidelines in emergency colorectal surgery.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

R AktimurDepartment of General Surgery, Samsun Education and Research Hospital, Ilkadim, Samsun, Turkey. recepaktimur@gmail.com.ORCID http://orcid.org/0000-0001-8781-9075
S CetinkunarDepartment of General Surgery, Adana Numune Education and Research Hospital, Adana, Turkey.
K YildirimDepartment of General Surgery, Samsun Education and Research Hospital, Ilkadim, Samsun, Turkey.
S H AktimurDepartment of Hematology, Faculty of Medicine, Ondokuz Mayis University, Samsun, Turkey.
M UgurlucanDepartment of Cardiovascular Surgery, Faculty of Medicine, Istanbul University, Istanbul, Turkey.
N OzlemDepartment of General Surgery, Samsun Education and Research Hospital, Ilkadim, Samsun, Turkey.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeDue to the diagnostic challenges and dreadful consequences of delayed treatment of acute mesenteric ischemia (AMI), a variety of diagnostic markers have been previously studied. However, the diagnostic value of neutrophil-to-lymphocyte ratio (NLR), which has been suggested to be a predictor of inflammation, has never been studied for AMI.

methodsThe data of 70 patients who underwent laparotomy (n = 8) and/or bowel resection (n = 62) for AMI (n = 70) between January 2009 and March 2014 were retrospectively analyzed. To investigate the studied parameters' role in the differential diagnosis of AMI, control groups were selected from most common reasons of inflammation-related emergent surgery, acute appendicitis (AA, n = 62) and normal appendix (NA, n = 61). White blood cell (WBC), red cell distribution width (RDW), NLR and mean platelet volume (MPV) values were recorded. Outcome variables of the study were defined as diagnostic and prognostic role of NLR in AMI.

resultsRDW and NLR values were found to be higher in the AMI group than the AA group (p < 0.001 and p < 0.001). Also, WBC and MPV values were higher in the AMI group than the NA group (p = 0.001 and p < 0.001). Combined sensitivity, specificity, positive predictive value and negative predictive value of RDW and NLR for recommended cut-off values were 69.4, 71.2, 57.8 and 80.4 %, respectively.

conclusionHigh NLR value (>9.9) seems to be a valuable diagnostic marker of acute mesenteric ischemia. Combined use of NLR, RDW and other clinical assessment, could help the diagnosis of AMI, especially in the absence of advanced imaging modalities and expert radiologic interpretation.

Indexed as

Abdominal PainAcute DiseaseAdolescentAdultAgedAged, 80 and overBiomarkersComorbidityFemaleHumansInflammationLymphocytesMaleMesenteric IschemiaMiddle AgedNeutrophilsBiomarkersAcute mesenteric ischemiaDiagnosisDifferential diagnosisMean platelet volumeNeutrophil-to-lymphocyte ratioRed cell distribution width

Identifiers

PMID26059561

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.