ArticleScientific reports2015
Pentamethylquercetin (PMQ) reduces thrombus formation by inhibiting platelet function.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 39 citations in OpenAlex.
- Post-operative epidural haematoma as complication of overconsumption of dried fruit in lumbar spinal surgery: a case report and review of the literature.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2024Review
- The mechanism of oleic acid inhibiting platelet activation stimulated by collagen.Cell communication and signaling : CCS · 2023Article
- A Hemodynamic Analysis of the Thrombosis Within Occluded Coronary Arterial Fistulas With Terminal Aneurysms Using a Blood Stasis Model.Frontiers in physiology · 2022Article
- Neuroprotective Effects of Quercetin on Ischemic Stroke: A Literature Review.Frontiers in pharmacology · 2022Review
- Current and Novel Antiplatelet Therapies for the Treatment of Cardiovascular Diseases.International journal of molecular sciences · 2021Review
- Sanguinarine Attenuates Collagen-Induced Platelet Activation and Thrombus Formation.Biomedicines · 2021Article
- Intravital Assessment of Blood Platelet Function. A Review of the Methodological Approaches with Examples of Studies of Selected Aspects of Blood Platelet Function.International journal of molecular sciences · 2020Review
- Factors Affecting the Formation and Treatment of Thrombosis by Natural and Synthetic Compounds.International journal of molecular sciences · 2020Review
- Simulation of thrombosis in a stenotic microchannel: The effects of vWF-enhanced shear activation of platelets.International journal of engineering science · 2020Article
- N-acetylcysteine inhibits thrombosis in a murine model of myeloproliferative neoplasm.Blood advances · 2020Article
- VAMP3 and SNAP23 as Potential Targets for Preventing the Disturbed Flow-Accelerated Thrombus Formation.Frontiers in cell and developmental biology · 2020Article
- Role of flavonoids in thrombotic, cardiovascular, and inflammatory diseases.Inflammopharmacology · 2019Review
- Synthetic Flavonoids as Novel Modulators of Platelet Function and Thrombosis.International journal of molecular sciences · 2019Review
- Pharmacological actions of miltirone in the modulation of platelet function.Acta pharmacologica Sinica · 2019Article
- Cancer cell-derived immunoglobulin G activates platelets by binding to platelet FcγRIIa.Cell death & disease · 2019Article
- Protective effects of gelsolin in acute pulmonary thromboembolism and thrombosis in the carotid artery of mice.PloS one · 2019Article
- A simple and effective preparation of quercetin pentamethyl ether from quercetin.Beilstein journal of organic chemistry · 2018Article
- Platelet releasates promote the proliferation of hepatocellular carcinoma cells by suppressing the expression of KLF6.Scientific reports · 2017Article
- Multi-Constituent Simulation of Thrombus Deposition.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Flavonoids exert both anti-oxidant and anti-platelet activities in vitro and in vivo. Pentamethylquercetin (PMQ), a polymethoxylated flavone derivative, has been screened for anti-carcinogenic and cardioprotective effects. However, it is unclear whether PMQ has anti-thrombotic effects. In the present study, PMQ (20 mg/kg) significantly inhibited thrombus formation in the collagen- epinephrine- induced acute pulmonary thrombosis mouse model and the ferric chloride-induced carotid injury model. To explore the mechanism, we evaluated the effects of PMQ on platelet function. We found that PMQ inhibited platelet aggregation and granule secretion induced by low dose agonists, including ADP, collagen, thrombin and U46619. Biochemical analysis revealed that PMQ inhibited collagen-, thrombin- and U46619-induced activation of Syk, PLCγ2, Akt, GSK3β and Erk1/2. Therefore, we provide the first report to show that PMQ possesses anti-thrombotic activity in vivo and inhibited platelet function in vitro, suggesting that PMQ may represent a potential therapeutic candidate for the prevention or treatment of thrombotic disorders.
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