Evidence map›Paper›PMID 26059497›Full record

Trial reportEuropean archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry2015

Effect of a chlorhexidine/thymol and a fluoride varnish on caries development in erupting permanent molars: a comparative study.

S Flamee, S Gizani, C Caroni, L Papagiannoulis, S Twetman

Abstract readComparative StudyRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.5field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 15 citations in OpenAlex.

  1. Trial
  2. Review
  3. The Current Strategies in Controlling Oral Diseases by Herbal and Chemical Materials.Evidence-based complementary and alternative medicine : eCAM · 2021
    Review
  4. Article
  5. Dose-response evaluation of a copaiba-containing varnish against streptococcus mutans in vivo.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2019
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

S FlameeDepartment of Paediatric Dentistry, Dental School, National and Kapodistrian University of Athens, 2 Thivon Str, Goudi, 11527, Athens, Greece.
S GizaniDepartment of Paediatric Dentistry, Dental School, National and Kapodistrian University of Athens, 2 Thivon Str, Goudi, 11527, Athens, Greece. stgizani@dent.uoa.gr.
C CaroniDepartment of Mathematics, National Technical University of Athens, 9 Heroon Polytechniou str, 15780, Zografou, Athens, Greece.
L PapagiannoulisDepartment of Paediatric Dentistry, Dental School, National and Kapodistrian University of Athens, 2 Thivon Str, Goudi, 11527, Athens, Greece.
S TwetmanDepartment of Odontology, Faculty of Health and Medical Sciences, University of Copenhagen, Nørre Allé 20, 2200, Copenhagen N, Denmark.
National and Kapodistrian University of Athens · GRNational Technical University of Athens · GRUniversity of Copenhagen · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo compare the caries preventive effect of a chlorhexidine/thymol-containing antibacterial varnish with a fluoride varnish when topically applied during the eruption of permanent molars.

methodsThe study group consisted of 189 patients, 5-14 years of age, with one 1st or 2nd permanent molar in the process of eruption. After stratification for type of molar and stage of eruption, the patients were randomised to either quarterly topical applications with an antibacterial varnish (Cervitec(®) Plus; CV group) or biannual applications with a fluoride varnish plus biannual treatments with placebo varnish (Fluor Protector; FV group). The duration of the study was 2 years. The primary endpoint was caries incidence (initial and cavitated) in the erupting molars and the secondary outcome was salivary mutans streptococci (MS) counts.

resultsThe groups were balanced with respect to socio-economy, oral hygiene, dietary habits and caries experience at baseline. The dropout rate was 11.6 %. The caries incidence was low (< 10 %) in both groups and there was no significant difference between the CV and FV groups with respect to occlusal caries development in the erupting molars (relative risk 1.08, 95 % CI 0.94-1.25). Significantly lower levels of salivary MS were disclosed in the CV group at the end of the study (p < 0.05).

conclusionsNo difference in occlusal caries development in young permanent molars was displayed after topical applications of either a chlorhexidine/thymol varnish or a fluoride varnish during tooth eruption.

Indexed as

Tooth EruptionAdolescentAnti-Infective Agents, LocalBacterial LoadCariostatic AgentsChildChild, PreschoolChlorhexidineDental CariesDental PlaqueDMF IndexDrug CombinationsFeeding BehaviorFluorides, TopicalHumansMolarAnti-Infective Agents, LocalCariostatic AgentsChlorhexidinechlorhexidine, thymol drug combinationDrug CombinationsFluorides, TopicalFluor ProtectorPolyurethanesSilanesThymolAntibacterial agentsChildrenDental varnishesFissure cariesMutans streptococci

Identifiers

PMID26059497
OpenAlexW611603214

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.