SynthesisOncotarget2015
Meta-analysis of organ-specific differences in the structure of the immune infiltrate in major malignancies.
Synthesis in Oncotarget, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 40 citations in OpenAlex.
- Towards the development of next-generation lung cancer immunotherapy.Translational lung cancer research · 2025Review
- Spatial modelling of the tumor microenvironment from multiplex immunofluorescence images: methods and applications.Frontiers in immunology · 2023Article
- Evaluating prognostic value and relevant gene signatures of tumor microenvironment characterization in esophageal carcinoma.Journal of gastrointestinal oncology · 2021Article
- The immune contexture and Immunoscore in cancer prognosis and therapeutic efficacy.Nature reviews. Cancer · 2020Review
- Assessment of long non-coding RNA expression reveals novel mediators of the lung tumour immune response.Scientific reports · 2020Article
- Article
- Chemokines modulate the tumour microenvironment in pituitary neuroendocrine tumours.Acta neuropathologica communications · 2019Article
- Targeting Vascular Endothelial Growth Factor in Oesophagogastric Cancer: A Review of Progress to Date and Immunotherapy Combination Strategies.Frontiers in oncology · 2019Review
- Review
- The immune contexture in cancer prognosis and treatment.Nature reviews. Clinical oncology · 2017Review
- HYPE or HOPE: the prognostic value of infiltrating immune cells in cancer.British journal of cancer · 2017Review
- Data normalization considerations for digital tumor dissection.Genome biology · 2017Article
- Dual Functional Capability of Dendritic Cells - Cytokine-Induced Killer Cells in Improving Side Effects of Colorectal Cancer Therapy.Frontiers in pharmacology · 2017Review
- Calreticulin expression: Interaction with the immune infiltrate and impact on survival in patients with ovarian and non-small cell lung cancer.Oncoimmunology · 2016Article
- Biomarkers of immunogenic stress in metastases from melanoma patients: Correlations with the immune infiltrate.Oncoimmunology · 2016Article
- The presence of LC3B puncta and HMGB1 expression in malignant cells correlate with the immune infiltrate in breast cancer.Autophagy · 2016Article
- Article
- Immunosurveillance in esophageal carcinoma: The decisive impact of regulatory T cells.Oncoimmunology · 2016Article
- Differences in the composition of the immune infiltrate in breast cancer, colorectal carcinoma, melanoma and non-small cell lung cancer: A microarray-based meta-analysis.Oncoimmunology · 2016Article
- Editorial: Immunogenic Cell Death in Cancer: From Benchside Research to Bedside Reality.Frontiers in immunology · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Anticancer immunosurveillance is one of the major endogenous breaks of tumor progression. Here, we analyzed gene expression pattern indicative of the presence of distinct leukocyte subtypes within four cancer types (breast cancer, colorectal carcinoma, melanoma, and non-small cell lung cancer) and 20 different microarray datasets corresponding to a total of 3471 patients. Multiple metagenes reflecting the presence of such immune cell subtypes were highly reproducible across distinct cohorts. Nonetheless, there were sizable differences in the correlation patterns among such immune-relevant metagenes across distinct malignancies. The reproducibility of the correlations among immune-relevant metagenes was highest in breast cancer (followed by colorectal cancer, non-small cell lung cancer and melanoma), reflecting the fact that mammary carcinoma has an intrinsically better prognosis than the three other malignancies. Among breast cancer patients, we found that the expression of a lysosomal enzyme-related metagene centered around ASAH1 (which codes for N-acylsphingosine amidohydrolase-1, also called acid ceramidase) exhibited a higher correlation with multiple immune-relevant metagenes in patients that responded to neoadjuvant chemotherapy than in non-responders. Altogether, this meta-analysis revealed novel organ-specific features of the immune infiltrate in distinct cancer types, as well as a strategy for defining new prognostic biomarkers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.