ArticleScientific reports2015
Identification of a Mutation in FGF23 Involved in Mandibular Prognathism.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.
- Genes and Pathways Associated with Skeletal Sagittal Malocclusions: A Systematic Review.International journal of molecular sciences · 2021Pooled it
- Exploring the role ofFrontiers in physiology · 2026Article
- Genetic and Molecular Determinants of Familial Transmission of Skeletal Malocclusions.Orthodontics & craniofacial research · 2025Review
- Genetic factors underlying Mandibular prognathism: insights from recent human and animal studies.Mammalian genome : official journal of the International Mammalian Genome Society · 2025Review
- METTL3-dependent mCell death & disease · 2024Article
- Towards Genetic Dissection of Skeletal Class III Malocclusion: A Review of Genetic Variations Underlying the Phenotype in Humans and Future Directions.Journal of clinical medicine · 2023Article
- Skeletal Class III Malocclusion Is Associated withInternational journal of molecular sciences · 2022Article
- Article
- Targeted sequencing of NOTCH signaling pathway genes and association analysis of variants correlated with mandibular prognathism.Head & face medicine · 2021Article
- Genetics of Dentofacial and Orthodontic Abnormalities.Global medical genetics · 2020Review
- Mutant hFGF23(A12D) stimulates osteoblast differentiation through FGFR3.Journal of cellular and molecular medicine · 2019Article
- Heredity, Genetics and Orthodontics - How Much Has This Research Really Helped?Seminars in orthodontics · 2017Article
- Expressional Analysis of MSX1 (Human) Revealed its Role in Sagittal Jaw Relationship.Journal of clinical and diagnostic research : JCDR · 2017Article
- Targeted sequencing in FGF/FGFR genes and association analysis of variants for mandibular prognathism.Medicine · 2017Observational
- Candidate gene analyses of 3-dimensional dentoalveolar phenotypes in subjects with malocclusion.American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics · 2017Article
- An integrated genomic approach for the study of mandibular prognathism in the European seabass (Dicentrarchus labrax).Scientific reports · 2016Article
- Classification and characterization of class III malocclusion in Chinese individuals.Head & face medicine · 2016Article
- Association between Tooth Agenesis and Skeletal Malocclusions.Journal of oral & maxillofacial researchArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mandibular prognathism (MP) is a severe maxillofacial disorder with undetermined genetic background. We collected a Chinese pedigree with MP which involved in 23 living members of 4 generations. Genome-wide linkage analysis were carried out to obtain the information in this family and a new MP-susceptibility locus, 12pter-p12.3 was identified. Whole-exome sequencing identified a novel heterozygous mutation in fibroblast growth factor (FGF) 23 (; p.A12D) which well segregated with MP in this pedigree within the locus. The mutation was also detected in 3 cases out of 65 sporadic MP patients, but not in any of the 342 control subjects. The p.A12D mutation may disrupt signal peptide function and inhibit secretory in FGF23. Furthermore, mutant FGF23 was overexpressed in 293T cells, increased cytoplasmic accumulation was observed compared with the wild type. We have discovered that c.35C>A mutation in FGF23 strongly associated with MP, which expand our understanding of the genetic contribution to MP pathogenesis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.