ReviewCurrent topics in medicinal chemistry2015
The Role of Uric Acid and Methyl Derivatives in the Prevention of Age-Related Neurodegenerative Disorders.
Review in Current topics in medicinal chemistry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 39 citations in OpenAlex.
- Allopurinol Reprograms Uric Acid Self-Assembly by Disrupting Cytotoxic Fibrils and Redirecting Crystal Growth.JACS Au · 2025Article
- Xanthine Oxidoreductase: A Double-Edged Sword in Neurological Diseases.Antioxidants (Basel, Switzerland) · 2025Review
- A study on the role of serum uric acid in differentiating acute inflammatory demyelinating polyneuropathy from acute-onset chronic inflammatory demyelinating polyneuropathy.European journal of neurology · 2024Article
- Did Suetonius really call gout morbus dominorum? A philological and historico-medical reconstruction.Clinical rheumatology · 2023Article
- Hyperuricaemia Does Not Interfere with Aortopathy in a Murine Model of Marfan Syndrome.International journal of molecular sciences · 2023Article
- Intracellular DAMPs in Neurodegeneration and Their Role in Clinical Therapeutics.Molecular neurobiology · 2023Review
- Machine learning analysis of the UK Biobank reveals IGF-1 and inflammatory biomarkers predict Parkinson's disease risk.PloS one · 2023Article
- Hyperuricemia Increases the Risk of Atrial Fibrillation: A Systematic Review and Meta-Analysis.International journal of endocrinology · 2022Review
- Association between Serum Uric Acid Levels and Bone Mineral Density in Postmenopausal Women: A Cross-Sectional and Longitudinal Study.Healthcare (Basel, Switzerland) · 2021Article
- Brain lipid peroxidation and alzheimer disease: Synergy between the Butterfield and Mattson laboratories.Ageing research reviews · 2020Review
- Plasma creatinine and oxidative stress biomarkers in amyotrophic lateral sclerosis.Amyotrophic lateral sclerosis & frontotemporal degeneration · 2020Article
- Increased Cerebrospinal Fluid Uric Acid Levels in Guillain-Barré Syndrome.Frontiers in neurology · 2020Article
- Serum uric acid and left ventricular hypertrophy in hypertensive patients in Ado-Ekiti.The Pan African medical journal · 2020Article
- Association of sleep quality and sleep duration with serum uric acid levels in adults.PloS one · 2020Article
- Uric acid enhances longevity and endurance and protects the brain against ischemia.Neurobiology of aging · 2019Article
- Serum Uric Acid Is Highly Associated with Epilepsy Secondary to Cerebral Infarction.Neurotoxicity research · 2019Article
- Association between Serum Uric Acid and Oxidative Stress in Korean Adults.Korean journal of family medicine · 2018Article
- Diuretics: A possible keystone in upholding cognitive health.The mental health clinician · 2018Article
- Uric Acid Is Protective After Cerebral Ischemia/Reperfusion in Hyperglycemic Mice.Translational stroke research · 2017Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
High uric acid (UA levels have been correlated with a reduced risk of many neurodegenerative diseases through mechanisms involving chelating Fenton reaction transitional metals, antioxidant quenching of superoxide and hydroxyl free radicals, and as an electron donor that increases antioxidant enzyme activity (e.g. SOD. However, the clinical usefulness of UA is limited by its' low water solubility and propensity to form inflammatory crystals at hyperuricemic levels. This review focuses on the role of UA in neuroprotection, as well as potential strategies aimed at increasing UA levels in the soluble range, and the potential therapeutic use of more water-soluble methyl-UA derivatives from the natural catabolic end-products of dietary caffeine, theophylline, and theobromine.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.