ArticleThe Plant cell2015
The Arabidopsis Transcription Factor NAC016 Promotes Drought Stress Responses by Repressing AREB1 Transcription through a Trifurcate Feed-Forward Regulatory Loop Involving NAP.
Article in The Plant cell, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 121 papers.
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121 citing papers in PubMed, 249 citations in OpenAlex.
- QTL mapping for berry firmness and functional characterization of a prioritized candidate gene VvNAC83 in grape.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
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- Antagonistic regulation of nitrogen and drought signaling mediated by NIN-like protein 7 transcription factor inProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Knockout of the OsNAC113 Transcription Factor Causes High Salt Resistance in Rice.Plants (Basel, Switzerland) · 2025Article
- OsNTL2 confers rice osmotic stress resilience through coordinated transcriptional regulation of the ASC-GSH redox cycle and cell wall biosynthesis.Stress biology · 2025Article
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- Cell-Type Specific miRNA Regulatory Network Responses to ABA Stress Revealed by Time Series Transcriptional Atlases in Arabidopsis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- PcNAC25, a NAC transcription factor of Pugionium cornutum(L.) Gaertn conferring enhanced drought and salt stress tolerances in Arabidopsis.Scientific reports · 2025Article
- Characterization of the NAC gene family in 'Fengdan' peony (Frontiers in plant science · 2025Article
- Identification ofPlants (Basel, Switzerland) · 2024Article
- Genome-Wide Identification and Expression Analysis ofPlants (Basel, Switzerland) · 2024Article
- Transcriptomic Analysis Reveals the Mechanism of Color Formation in the Peel of an Evergreen Pomegranate Cultivar 'Danruo No.1' During Fruit Development.Plants (Basel, Switzerland) · 2024Article
- The NAC056 transcription factor confers freezing tolerance by positively regulating expression of CBFs and NIA1 in Arabidopsis.Plant communications · 2024Article
- Common Bean (International journal of molecular sciences · 2024Article
- NACs strike again: NOR-like1 is responsible for cuticle development in tomato fruit.Journal of experimental botany · 2024Article
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- Mining of disease-resistance genes inFrontiers in genetics · 2024Article
- NACs, generalist in plant life.Plant biotechnology journal · 2023Review
61 more citing papers are in PubMed but not listed here.
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5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Drought and other abiotic stresses negatively affect plant growth and development and thus reduce productivity. The plant-specific NAM/ATAF1/2/CUC2 (NAC) transcription factors have important roles in abiotic stress-responsive signaling. Here, we show that Arabidopsis thaliana NAC016 is involved in drought stress responses; nac016 mutants have high drought tolerance, and NAC016-overexpressing (NAC016-OX) plants have low drought tolerance. Using genome-wide gene expression microarray analysis and MEME motif searches, we identified the NAC016-specific binding motif (NAC16BM), GATTGGAT[AT]CA, in the promoters of genes downregulated in nac016-1 mutants. The NAC16BM sequence does not contain the core NAC binding motif CACG (or its reverse complement CGTG). NAC016 directly binds to the NAC16BM in the promoter of ABSCISIC ACID-RESPONSIVE ELEMENT BINDING PROTEIN1 (AREB1), which encodes a central transcription factor in the stress-responsive abscisic acid signaling pathway and represses AREB1 transcription. We found that knockout mutants of the NAC016 target gene NAC-LIKE, ACTIVATED BY AP3/PI (NAP) also exhibited strong drought tolerance; moreover, NAP binds to the AREB1 promoter and suppresses AREB1 transcription. Taking these results together, we propose that a trifurcate feed-forward pathway involving NAC016, NAP, and AREB1 functions in the drought stress response, in addition to affecting leaf senescence in Arabidopsis.
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