ArticleScientific reports2015
Modelling the Transport of Nanoparticles under Blood Flow using an Agent-based Approach.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed.
- From Design to Bedside: Brain-Targeted Engineered Nanoparticles and Predictive Modeling for Neurodegenerative Diseases Therapeutics.Pharmaceutical research · 2026Review
- Green Synthesis of Bioactive Silver Nanoparticles fromPharmaceutics · 2025Article
- Emerging nanoparticle-based x-ray imaging contrast agents for breast cancer screening.Nanomedicine (London, England) · 2025Review
- The pathways for nanoparticle transport across tumour endothelium.Nature nanotechnology · 2025Article
- Computational fluid dynamics modeling and simulation of nanoparticle-tumor interaction: Systematic literature review.Computational and structural biotechnology journal · 2025Review
- Modeling of spatiotemporal dynamics of ligand-coated particle flow in targeted drug delivery processes.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Achieving Precision Healthcare through Nanomedicine and Enhanced Model Systems.ACS materials Au · 2024Review
- A Novel Experimental Approach to Understand the Transport of Nanodrugs.Materials (Basel, Switzerland) · 2023Article
- Rational nanoparticle design: Optimization using insights from experiments and mathematical models.Journal of controlled release : official journal of the Controlled Release Society · 2023Review
- Size-Dependent Polymeric Nanoparticle Distribution in a Static versus Dynamic Microfluidic Blood Vessel Model: Implications for Nanoparticle-Based Drug Delivery.ACS applied nano materials · 2023Article
- Agent-Based Modeling of Complex Molecular Systems.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Cancer nanotechnology: current status and perspectives.Nano convergence · 2021Review
- Disturbance of cellular homeostasis as a molecular risk evaluation of human endothelial cells exposed to nanoparticles.Scientific reports · 2021Article
- Analysis of mechanotransduction dynamics during combined mechanical stimulation and modulation of the extracellular-regulated kinase cascade uncovers hidden information within the signalling noise.Interface focus · 2021Article
- Biomedical nanomaterials for immunological applications: ongoing research and clinical trials.Nanoscale advances · 2020Review
- The Convergence of Cell-Based Surface Plasmon Resonance and Biomaterials: The Future of Quantifying Bio-molecular Interactions-A Review.Annals of biomedical engineering · 2020Review
- Nanoinformatics and biomolecular nanomodeling: a novel move en route for effective cancer treatment.Environmental science and pollution research international · 2020Review
- The FLAME-accelerated signalling tool (FaST) for facile parallelisation of flexible agent-based models of cell signalling.NPJ systems biology and applications · 2020Article
- Revealing hidden information in osteoblast's mechanotransduction through analysis of time patterns of critical events.BMC bioinformatics · 2020Article
- A mathematical model to predict nanomedicine pharmacokinetics and tumor delivery.Computational and structural biotechnology journal · 2020Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Blood-mediated nanoparticle delivery is a new and growing field in the development of therapeutics and diagnostics. Nanoparticle properties such as size, shape and surface chemistry can be controlled to improve their performance in biological systems. This enables modulation of immune system interactions, blood clearance profile and interaction with target cells, thereby aiding effective delivery of cargo within cells or tissues. Their ability to target and enter tissues from the blood is highly dependent on their behaviour under blood flow. Here we have produced an agent-based model of nanoparticle behaviour under blood flow in capillaries. We demonstrate that red blood cells are highly important for effective nanoparticle distribution within capillaries. Furthermore, we use this model to demonstrate how nanoparticle size can selectively target tumour tissue over normal tissue. We demonstrate that the polydispersity of nanoparticle populations is an important consideration in achieving optimal specificity and to avoid off-target effects. In future this model could be used for informing new nanoparticle design and to predict general and specific uptake properties under blood flow.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.