SynthesisThe Cochrane database of systematic reviews2015
Snake antivenom for snake venom induced consumption coagulopathy.
Synthesis in The Cochrane database of systematic reviews, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 5 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- Strokes following snakebite envenomations: A systematic review and individual patient data meta-analysis.PLoS neglected tropical diseases · 2025Pooled it
- Outcomes in intervention research on snakebite envenomation: a systematic review.F1000Research · 2022Pooled it
- Clinical outcomes and outcome measurement tools reported in randomised controlled trials of treatment for snakebite envenoming: A systematic review.PLoS neglected tropical diseases · 2021Pooled it
- Scorpion envenomation: state of the art.Intensive care medicine · 2020Pooled it
- Snake antivenom for snake venom induced consumption coagulopathy.The Cochrane database of systematic reviews · 2015Pooled it
- A randomized controlled trial of fresh frozen plasma for coagulopathy in Russell's viper (Daboia russelii) envenoming.Journal of thrombosis and haemostasis : JTH · 2017Trial
- Article
- Fibrinogen supplementation enhances antivenom efficacy in treating coagulopathy due to hemotoxic snakebite envenoming byFrontiers in medicine · 2025Article
- Electrophysiological evaluation of the neuromuscular junction: a brief review.Arquivos de neuro-psiquiatria · 2023Review
- Article
- Indian Polyvalent Antivenom Accelerates Recovery From Venom-Induced Consumption Coagulopathy (VICC) in Sri Lankan Russell's Viper (Frontiers in medicine · 2022Article
- Interventions for the management of snakebite envenoming: An overview of systematic reviews.PLoS neglected tropical diseases · 2020Review
- Snakebites in Suriname: Evaluation of the Protocolled Administration of Anti-Snake Venom in a Tertiary Care Setting.The American journal of tropical medicine and hygiene · 2020Article
- Enzyme immunoassays for detection and quantification of venoms of Sri Lankan snakes: Application in the clinical setting.PLoS neglected tropical diseases · 2020Article
- Bedside Coagulation Tests in Diagnosing Venom-Induced Consumption Coagulopathy in Snakebite.Toxins · 2020Review
- High mortality due to snakebites in French Guiana: Time has come to re-evaluate medical management protocols.PLoS neglected tropical diseases · 2018Article
- Article
- Therapeutics in clinical toxicology: in the absence of strong evidence how do we choose between antidotes, supportive care and masterful inactivity.British journal of clinical pharmacology · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSnake venom induced consumption coagulopathy is a major systemic effect of envenoming. Observational studies suggest that antivenom improves outcomes for venom induced consumption coagulopathy in some snakebites and not others. However, the effectiveness of snake antivenom in all cases of venom induced consumption coagulopathy is controversial.
objectivesTo assess the effect of snake antivenom as a treatment for venom induced consumption coagulopathy in people with snake bite. SEARCH
methodsThe search was done on 30 January 2015. We searched the Cochrane Injuries Group's Specialised Register, the Cochrane Central Register of Controlled Trials (CENTRAL, The Cochrane Library), Ovid MEDLINE(R), Ovid MEDLINE(R) In-Process & Other Non-Indexed Citations, Ovid MEDLINE(R) Daily and Ovid OLDMEDLINE(R), Embase Classic+Embase (OvidSP), three other sources, clinical trials registers, and we also screened reference lists. SELECTION CRITERIA: All completed, published or unpublished, randomised, controlled trials with a placebo or no treatment arm, where snake antivenom was administered for venom induced consumption coagulopathy in humans with snake bites. DATA COLLECTION AND ANALYSIS: Two authors reviewed the identified trials and independently applied the selection criteria. MAIN
resultsNo studies met the inclusion criteria for this review. AUTHORS'
conclusionsRandomised placebo-controlled trials are required to investigate the effectiveness of snake antivenom for clinically relevant outcomes in patients with venom induced consumption coagulopathy resulting from snake bite. Although ethically difficult, the routine administration of a treatment that has a significant risk of anaphylaxis cannot continue without strong evidence of benefit.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.