Evidence map›Paper›PMID 26058790›Full record

ArticleClinical research in cardiology : official journal of the German Cardiac Society2015

Effects of spironolactone on ventricular-arterial coupling in patients with chronic systolic heart failure and mild symptoms.

Enrico Vizzardi, Edoardo Sciatti, Ivano Bonadei, Antonio D'Aloia, Lamia Tartière-Kesri, Jean-Michel Tartière, Alain Cohen-Solal, Marco Metra

Abstract readControlled Clinical Trial
PubMed Publisher
In one paragraph

Article in Clinical research in cardiology : official journal of the German Cardiac Society, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 3 pooled it
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 3 syntheses or guidelines pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Timing of Left Ventricular Remodeling in Nonischemic Dilated Cardiomyopathy.The American journal of the medical sciences · 2018
    Trial
  5. Article
  6. Article
  7. Observational
  8. Article
  9. Article
  10. Association of mineralocorticoid receptor antagonist use and in-hospital outcomes in patients with acute heart failure.Clinical research in cardiology : official journal of the German Cardiac Society · 2018
    Observational
  11. Midregional proadrenomedullin and growth differentiation factor-15 are not influenced by obesity in heart failure patients.Clinical research in cardiology : official journal of the German Cardiac Society · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Enrico VizzardiSection of Cardiovascular Diseases, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Study of Brescia, Brescia, Italy. enrico.vizzardi@tin.it.
Edoardo SciattiSection of Cardiovascular Diseases, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Study of Brescia, Brescia, Italy.
Ivano BonadeiSection of Cardiovascular Diseases, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Study of Brescia, Brescia, Italy.
Antonio D'AloiaSection of Cardiovascular Diseases, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Study of Brescia, Brescia, Italy.
Lamia Tartière-KesriCardiac Rehabilitation, Léon Bérard Hospital, Hyères, France.
Jean-Michel TartièreCardiology Department, Sainte Musse Hospital, Toulon, France.
Alain Cohen-SolalCardiology Department, Lariboisière Hospital and Denis Diderot University, Paris, France.
Marco MetraSection of Cardiovascular Diseases, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Study of Brescia, Brescia, Italy.
University of Brescia · ITHôpital d'Instruction des Armées Sainte-Anne · FRInserm · FRUniversité Paris Cité · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSeveral studies demonstrated that mineralocorticoid receptor antagonists (MRAs) are able to prevent myocardial and vascular fibrosis, and left ventricular (LV) remodeling in patients with systolic chronic heart failure (HF) and mild symptoms. Ventricular-arterial coupling (VAC) should be influenced by anti-fibrotic interventions. We have assessed the effects of spironolactone on VAC and its components, aortic elastance (Ea) and end-systolic LV elastance (Ees), in patients with HF. METHODS AND

resultsChanges from baseline in VAC were compared between 65 patients treated with spironolactone and 32 controls not receiving MRAs. All patients had HF, reduced LVEF with reduced LV ejection fraction (LVEF) and New York Heart Association (NYHA) functional class I-II symptoms, and underwent transthoracic echocardiography at baseline and after 6 months. VAC was estimated by the modified single-beat method as Ea/Ees. Parameters of LV function improved after 6 month treatment with spironolactone with an increase in the LVEF from 34 ± 8 to 39 ± 8 % (p < 0.001). Spironolactone increased Ees from 1.32 ± 0.38 to 1.57 ± 0.42 mmHg/mL (p < 0.001) and reduced VAC from 2.03 ± 0.59 to 1.66 ± 0.31 (p < 0.001), but did not affect Ea and V0 (LV volume at end-systolic pressure of 0 mmHg). No change in any of these parameters occurred in the control group.

conclusions6-month therapy with spironolactone improved VAC mainly through its effect on Ees in patients with mild HF.

Indexed as

AgedEchocardiographyFemaleFollow-Up StudiesHeart Failure, SystolicHeart VentriclesHumansMaleMiddle AgedMineralocorticoid Receptor AntagonistsProspective StudiesSpironolactoneVentricular Dysfunction, LeftVentricular Function, LeftVentricular RemodelingMineralocorticoid Receptor AntagonistsSpironolactoneHeart failureMineralocorticoid receptor antagonistsModified single-beat methodVentricular-arterial coupling

Identifiers

PMID26058790
OpenAlexW2217213299

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.