ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2015
Lack of age-dependent decrease in dopamine D3 receptor availability: a [(11)C]-(+)-PHNO and [(11)C]-raclopride positron emission tomography study.
Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- A multi-pronged investigation of option generation using depression, PET and modafinil.Brain : a journal of neurology · 2022Trial
- Associations of neuromelanin in the substantia nigra with antipsychotic response in schizophrenia.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Dopamine DNeurochemical research · 2023Article
- Aging in nucleus accumbens and its impact on alcohol use disorders.Alcohol (Fayetteville, N.Y.) · 2023Review
- Evaluation of dopamine DPsychopharmacology · 2021Article
- A Gain-of-Function Variant in Dopamine D2 Receptor and Progressive Chorea and Dystonia Phenotype.Movement disorders : official journal of the Movement Disorder Society · 2021Article
- Association of dopamine DNeuroImage · 2020Article
- Disrupted-in-schizophrenia 1 functional polymorphisms and DGenes, brain, and behavior · 2019Article
- DRD2 Genotype-Based Variants Modulates D2 Receptor Distribution in Ventral Striatum.Molecular neurobiology · 2019Article
- GFrontiers in aging neuroscience · 2019Review
- Expression of dopamine D2 and D3 receptors in the human retina revealed by positron emission tomography and targeted mass spectrometry.Experimental eye research · 2018Article
- The relationship between subcortical brain volume and striatal dopamine DHuman brain mapping · 2017Article
- Article
- Regional and source-based patterns of [NeuroImage · 2017Article
- Elevated Dopamine DNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Article
- Age-related changes in binding of the D2/3 receptor radioligand [(11)C](+)PHNO in healthy volunteers.NeuroImage · 2016Article
- Exploring personality traits related to dopamine D2/3 receptor availability in striatal subregions of humans.European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2016Article
- Dopamine D₂/₃ receptor availability in the striatum of antipsychotic-free older patients with schizophrenia-A [¹¹C]-raclopride PET study.Schizophrenia research · 2015Article
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10 authors.
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Abstract
Positron emission tomography with antagonist radiotracers has showed that striatal dopamine D2/3 receptor (D2/3R) availability decreases with age. However, no study has specifically assessed whether D2/3R availability decreases with age in healthy persons as measured with agonist radiotracers. Moreover, it is unknown whether D3R availability changes with age in healthy humans. Thus, we explored the relationship between age and D2/3R availability in healthy humans using the D3 receptor (D3R)-preferential agonist radiotracer [(11)C]-(+)-PHNO (n=72, mean±s.d. age=40±15, range=18 to 73) and the antagonist [(11)C]-Raclopride (n=70, mean±s.d. age =40±14, range=18 to 73) (both, n=33). The contribution of D3R to the [(11)C]-(+)-PHNO signal varies across regions of interest; the substantia nigra and hypothalamus represent D3R-specific regions, the ventral pallidum, globus pallidus, and ventral striatum represent D2/3R-mixed regions, and the caudate and putamen represent D2 receptor (D2R)-specific regions. With [(11)C]-(+)-PHNO, a negative correlation was observed between age and nondisplaceable binding potential (BPND) in the caudate (r(70)=-0.32, P=0.005). No correlations were observed in the other regions. With [(11)C]-Raclopride, negative correlations were observed between age and BPND in the caudate (r(68)=-0.50, P<0.001), putamen (r(68)=-0.41, P<0.001), and ventral striatum (r(68)=-0.43, P<0.001). In conclusion, in contrast with the age-dependent decrease in D2R availability, these findings suggest that D3R availability does not change with age.
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