ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2015
White Matter Hyperintensity Accumulation During Treatment of Late-Life Depression.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 51 citations in OpenAlex.
- Behavioral and psychological symptoms of dementia associated with vascular impairment: a systematic review and meta-analysis.Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) · 2025Pooled it
- Longitudinal Changes of White Matter Hyperintensities in Sporadic Small Vessel Disease: A Systematic Review and Meta-analysis.Neurology · 2022Pooled it
- Trajectories in Cerebral Blood Flow Following Antidepressant Treatment in Late-Life Depression: Support for the Vascular Depression Hypothesis.The Journal of clinical psychiatry · 2018Trial
- Brain Tissue Pulsatility is Increased in Midlife Depression: a Comparative Study Using Ultrasound Tissue Pulsatility Imaging.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017Trial
- Longitudinal Changes in White Matter Hypointensities in Recurrent Late-Life Depression.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2026Article
- Region-specific vulnerability to vascular risk factors and modifiable protective influences on white matter hyperintensities.Communications medicine · 2026Article
- Moderators of treatment response in late-life depression.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Remission is insufficient: predictors and mechanistic models of recurrence in late-life depression.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- White matter hyperintensities and relapse risk in late-life depression.Journal of affective disorders · 2025Article
- Elevated brain pulsations in depression: insights from a pooled ultrasound cohort study.Interface focus · 2024Article
- White matter hyperintensities are an independent predictor of cognitive decline 3 years following first-ever stroke-results from the PROSCIS-B study.Journal of neurology · 2023Article
- Correlation Between Serum High-Sensitivity C-Reactive Protein, Tumor Necrosis Factor-Alpha, Serum Interleukin-6 and White Matter Integrity Before and After the Treatment of Drug-Naïve Patients With Major Depressive Disorder.Frontiers in neuroscience · 2022Article
- Relationship between illness duration, corpus callosum changes, and sustained attention dysfunction in major depressive disorder.Quantitative imaging in medicine and surgery · 2021Article
- Basal myokine levels are associated with quality of life and depressed mood in older adults.Psychophysiology · 2021Article
- Neuroimaging Biomarkers for Predicting Treatment Response and Recurrence of Major Depressive Disorder.International journal of molecular sciences · 2020Review
- Cognitive Reserve Moderates Effects of White Matter Hyperintensity on Depressive Symptoms and Cognitive Function in Late-Life Depression.Frontiers in psychiatry · 2020Article
- Neuroimaging of Small Vessel Disease in Late-Life Depression.Advances in experimental medicine and biology · 2019Article
- Oxygenation differs among white matter hyperintensities, intersected fiber tracts and unaffected white matter.Brain communications · 2019Article
- Linking late life depression and Alzheimer's disease: mechanisms and resilience.Current behavioral neuroscience reports · 2019Article
- Machine learning in major depression: From classification to treatment outcome prediction.CNS neuroscience & therapeutics · 2018Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
White matter hyperintensities (WMHs) have been shown to be associated with the development of late-life depression (LLD) and eventual treatment outcomes. This study sought to investigate longitudinal WMH changes in patients with LLD during a 12-week antidepressant treatment course. Forty-seven depressed elderly patients were included in this analysis. All depressed subjects started pharmacological treatment for depression shortly after a baseline magnetic resonance imaging (MRI) scan. At 12 weeks, patients underwent a follow-up MRI scan, and were categorized as either treatment remitters (n=23) or non-remitters (n=24). Among all patients, there was as a significant increase in WMHs over 12 weeks (t(46)=2.36, P=0.02). When patients were stratified by remission status, non-remitters demonstrated a significant increase in WMHs (t(23)=2.17, P=0.04), but this was not observed in remitters (t(22)=1.09, P=0.29). Other markers of brain integrity were also investigated including whole brain gray matter volume, hippocampal volume, and fractional anisotropy. No significant differences were observed in any of these markers during treatment, including when patients were stratified based on remission status. These results add to existing literature showing the association between WMH accumulation and LLD treatment outcomes. Moreover, this is the first study to demonstrate similar findings over a short interval (ie 12 weeks), which corresponds to the typical length of an antidepressant trial. These findings serve to highlight the acute interplay of cerebrovascular ischemic disease and LLD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.