ArticleNMR in biomedicine2015
Dynamic oxygen challenge evaluated by NMR T1 and T2*--insights into tumor oxygenation.
Article in NMR in biomedicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
34 citing papers in PubMed, 49 citations in OpenAlex.
- Dependency of the blood oxygen level dependent-response to hyperoxic challenges on the order of gas administration in intracranial malignancies.Neuroradiology · 2019Trial
- Whole-Body Oxygen-Enhanced MRI of Tumor-Bearing Mice Under Hyperbaric Oxygenation.Magnetic resonance in medicine · 2026Article
- Combining Oxygen-Enhanced MRI and Electron Paramagnetic Resonance Oximetry for Quantitative OE-MRI (qOE-MRI) as a Method for Mapping Absolute Oxygen Levels (pOMagnetic resonance in medicine · 2026Article
- MRI for biology-guided radiation therapy: Are we there yet? A summary of the 2024 ISMRM member-initiated session.Magnetic resonance in medicine · 2025Review
- Blood-oxygenation-level-dependent (BOLD) MRI responses to COMagnetic resonance imaging · 2025Article
- Evaluations of an Early Change in Tumor Pathophysiology in Response to Radiotherapy with Oxygen Enhanced Electron Paramagnetic Resonance Imaging (OE EPRI).Molecular imaging and biology · 2024Article
- Re-examining What the Results of "a Measurement of Oxygen Level in Tissues" Really Mean.Molecular imaging and biology · 2024Article
- Functional Imaging of Hypoxia: PET and MRI.Cancers · 2023Review
- TThe British journal of radiology · 2023Article
- Oxygen-enhanced MRI and radiotherapy in patients with oropharyngeal squamous cell carcinoma.Clinical and translational radiation oncology · 2023Article
- Oxygen-Sensitive MRI: A Predictive Imaging Biomarker for Tumor Radiation Response?International journal of radiation oncology, biology, physics · 2021Article
- Non-Invasive Evaluation of Acute Effects of Tubulin Binding Agents: A Review of Imaging Vascular Disruption in Tumors.Molecules (Basel, Switzerland) · 2021Review
- Optimal Control Theory for Personalized Therapeutic Regimens in Oncology: Background, History, Challenges, and Opportunities.Journal of clinical medicine · 2020Review
- Oxygen-enhanced MRI MOLLI T1 mapping during chemoradiotherapy in anal squamous cell carcinoma.Clinical and translational radiation oncology · 2020Article
- Article
- Oxygen-sensitive MRI assessment of tumor response to hypoxic gas breathing challenge.NMR in biomedicine · 2019Article
- The effect of flow on blood oxygen level dependent (RMagnetic resonance in medicine · 2019Article
- Molecular and functional imaging insights into the role of hypoxia in cancer aggression.Cancer metastasis reviews · 2019Review
- Imaging tumour hypoxia with oxygen-enhanced MRI and BOLD MRI.The British journal of radiology · 2019Review
- Examining correlations of oxygen sensitive MRI (BOLD/TOLD) with [American journal of nuclear medicine and molecular imaging · 2019Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
Abstract
There is intense interest in developing non-invasive prognostic biomarkers of tumor response to therapy, particularly with regard to hypoxia. It has been suggested that oxygen sensitive MRI, notably blood oxygen level-dependent (BOLD) and tissue oxygen level-dependent (TOLD) contrast, may provide relevant measurements. This study examined the feasibility of interleaved T2*- and T1-weighted oxygen sensitive MRI, as well as R2* and R1 maps, of rat tumors to assess the relative sensitivity to changes in oxygenation. Investigations used cohorts of Dunning prostate R3327-AT1 and R3327-HI tumors, which are reported to exhibit distinct size-dependent levels of hypoxia and response to hyperoxic gas breathing. Proton MRI R1 and R2* maps were obtained for tumors of anesthetized rats (isoflurane/air) at 4.7 T. Then, interleaved gradient echo T2*- and T1-weighted images were acquired during air breathing and a 10 min challenge with carbogen (95% O2 -5% CO2). Signals were stable during air breathing, and each type of tumor showed a distinct signal response to carbogen. T2* (BOLD) response preceded T1 (TOLD) responses, as expected. Smaller HI tumors (reported to be well oxygenated) showed the largest BOLD and TOLD responses. Larger AT1 tumors (reported to be hypoxic and resist modulation by gas breathing) showed the smallest response. There was a strong correlation between BOLD and TOLD signal responses, but ΔR2* and ΔR1 were only correlated for the HI tumors. The magnitude of BOLD and TOLD signal responses to carbogen breathing reflected expected hypoxic fractions and oxygen dynamics, suggesting potential value of this test as a prognostic biomarker of tumor hypoxia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.