ArticleDevelopmental neurobiology2016
Long-term stability of axonal boutons in the mouse barrel cortex.
Article in Developmental neurobiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 42 citations in OpenAlex.
- Local Protein Synthesis at Synapses: A Driver for Synapse Diversification.Journal of neurochemistry · 2025Review
- Super-resolution imaging of fast morphological dynamics of neurons in behaving animals.Nature methods · 2025Article
- Contextual Fear Learning and Extinction in the Primary Visual Cortex of Mice.Neuroscience bulletin · 2023Article
- Engineered synaptic tools reveal localized cAMP signaling in synapse assembly.The Journal of cell biology · 2022Article
- Organization of Presynaptic Autophagy-Related Processes.Frontiers in synaptic neuroscience · 2022Review
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- Synaptic remodeling in mouse motor cortex after spinal cord injury.Neural regeneration research · 2021Article
- Sensory Experience as a Regulator of Structural Plasticity in the Developing Whisker-to-Barrel System.Frontiers in cellular neuroscience · 2021Article
- Caspase inhibition rescues F1Fo ATP synthase dysfunction-mediated dendritic spine elimination.Scientific reports · 2020Article
- Structural dynamics and stability of corticocortical and thalamocortical axon terminals during motor learning.PloS one · 2020Article
- Dendritic Spine Plasticity: Function and Mechanisms.Frontiers in synaptic neuroscience · 2020Article
- Presynaptic Boutons That Contain Mitochondria Are More Stable.Frontiers in synaptic neuroscience · 2019Article
- Identification of genes associated with cortical malformation using a transposon-mediated somatic mutagenesis screen in mice.Nature communications · 2018Article
- Size-Dependent Axonal Bouton Dynamics following Visual Deprivation In Vivo.Cell reports · 2018Article
- The Glutamatergic System in Primary Somatosensory Neurons and Its Involvement in Sensory Input-Dependent Plasticity.International journal of molecular sciences · 2017Review
- Review
- Molecular Neuroscience in the 21Neuron · 2017Review
- Article
- Closing the gap: long-term presynaptic plasticity in brain function and disease.Current opinion in neurobiology · 2017Review
- Long-term depression-associated signaling is required for an in vitro model of NMDA receptor-dependent synapse pruning.Neurobiology of learning and memory · 2017Article
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Many lines of evidence indicate that postsynaptic dendritic spines are plastic during development and largely stable in adulthood. It remains unclear to what degree presynaptic axonal terminals undergo changes in the developing and mature cortex. In this study, we examined the formation and elimination of fluorescently-labeled axonal boutons in the living mouse barrel cortex with transcranial two-photon microscopy. We found that the turnover of axonal boutons was significantly higher in 3-week-old young mice than in adult mice (older than 3 months). There was a slight but significant net loss of axonal boutons in mice from 1 to 2 months of age. In both young and adult barrel cortex, axonal boutons existed for at least 1 week were less likely to be eliminated than those recently-formed boutons. In adulthood, 80% of axonal boutons persisted over 12 months and enriched sensory experience caused a slight but not significant increase in the turnover of axonal boutons over 2-4 weeks. Thus, similar to postsynaptic dendritic spines, presynaptic axonal boutons show remarkable stability after development ends. This long-term stability of synaptic connections is likely important for reliable sensory processing in the mature somatosensory cortex.
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