ArticleGenome biology and evolution2015
Spider Transcriptomes Identify Ancient Large-Scale Gene Duplication Event Potentially Important in Silk Gland Evolution.
Article in Genome biology and evolution, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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41 citing papers in PubMed, 81 citations in OpenAlex.
- Big Spider, Big Genome: Chromosome-Level Genome of a North American Tarantula (Aphonopelma marxi) and Comparative Genomics Across 300 Million Years of Spider Evolution.Genome biology and evolution · 2026Article
- Gene and Genome Duplication in Spiders.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2025Review
- Review
- Quantitative Shotgun Proteomic Analysis of Bacteria after Overexpression of Recombinant Spider Miniature Spidroin, MaSp1.International journal of molecular sciences · 2024Article
- Advances in genome sequencing reveal changes in gene content that contribute to arthropod macroevolution.Development genes and evolution · 2023Review
- Chromosome-level genome and the identification of sex chromosomes in Uloborus diversus.GigaScience · 2022Article
- Global gradients in the distribution of animal polyploids.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Genome size evolution in the diverse insect order Trichoptera.GigaScience · 2022Article
- Widespread retention of ohnologs in key developmental gene families following whole-genome duplication in arachnopulmonates.G3 (Bethesda, Md.) · 2021Article
- The Tetragnatha kauaiensis Genome Sheds Light on the Origins of Genomic Novelty in Spiders.Genome biology and evolution · 2021Article
- High mechanical property silk produced by transgenic silkworms expressing the spidroins PySp1 and ASG1.Scientific reports · 2021Article
- Protein Composition and Associated Material Properties of Cobweb Spiders' Gumfoot Glue Droplets.Integrative and comparative biology · 2021Article
- Morphological changes during the post-embryonic ontogeny of mesothelan spiders and aspects of character evolution in early spiders.Development genes and evolution · 2021Article
- Shifts in morphology, gene expression, and selection underlie web loss in Hawaiian Tetragnatha spiders.BMC ecology and evolution · 2021Article
- Chromosome-level reference genome of the European wasp spider Argiope bruennichi: a resource for studies on range expansion and evolutionary adaptation.GigaScience · 2021Article
- Widow spiders in the New World: a review onThe journal of venomous animals and toxins including tropical diseases · 2021Article
- Functional and Structural Variation among Sticholysins, Pore-Forming Proteins from the Sea AnemoneInternational journal of molecular sciences · 2020Review
- Multi-faceted analysis provides little evidence for recurrent whole-genome duplications during hexapod evolution.BMC biology · 2020Article
- Insights into the Synthesis, Secretion and Curing of Barnacle Cyprid Adhesive via Transcriptomic and Proteomic Analyses of the Cement Gland.Marine drugs · 2020Article
- Ovarian Transcriptomic Analyses in the Urban Human Health Pest, the Western Black Widow Spider.Genes · 2020Article
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
Abstract
The evolution of specialized tissues with novel functions, such as the silk synthesizing glands in spiders, is likely an influential driver of adaptive success. Large-scale gene duplication events and subsequent paralog divergence are thought to be required for generating evolutionary novelty. Such an event has been proposed for spiders, but not tested. We de novo assembled transcriptomes from three cobweb weaving spider species. Based on phylogenetic analyses of gene families with representatives from each of the three species, we found numerous duplication events indicative of a whole genome or segmental duplication. We estimated the age of the gene duplications relative to several speciation events within spiders and arachnids and found that the duplications likely occurred after the divergence of scorpions (order Scorpionida) and spiders (order Araneae), but before the divergence of the spider suborders Mygalomorphae and Araneomorphae, near the evolutionary origin of spider silk glands. Transcripts that are expressed exclusively or primarily within black widow silk glands are more likely to have a paralog descended from the ancient duplication event and have elevated amino acid replacement rates compared with other transcripts. Thus, an ancient large-scale gene duplication event within the spider lineage was likely an important source of molecular novelty during the evolution of silk gland-specific expression. This duplication event may have provided genetic material for subsequent silk gland diversification in the true spiders (Araneomorphae).
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