Evidence map›Paper›PMID 26058342›Full record

ArticleAIDS research and human retroviruses2015

Genomic characterization of two novel HIV-1 unique (CRF01_AE/B) recombinant forms among men who have sex with men in Beijing, China.

Zheng Li, Jia Li, Yi Feng, Marcia L Kalish, Hongyan Lu, Lu Yin, Lingjie Liao, Han-Zhu Qian, Simon D W Frost, Yuhua Ruan and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in AIDS research and human retroviruses, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 8 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 2 countries.

Zheng Li1 State Key Laboratory for Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases , Beijing, China .
Jia Li2 Beijing Center for Disease Control and Prevention , Beijing, China .
Yi Feng1 State Key Laboratory for Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases , Beijing, China .
Marcia L Kalish3 Vanderbilt Institute for Global Health, Vanderbilt University School of Medicine , Nashville, Tennessee.
Hongyan Lu2 Beijing Center for Disease Control and Prevention , Beijing, China .
Lu Yin3 Vanderbilt Institute for Global Health, Vanderbilt University School of Medicine , Nashville, Tennessee.
Lingjie Liao1 State Key Laboratory for Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases , Beijing, China .
Han-Zhu Qian3 Vanderbilt Institute for Global Health, Vanderbilt University School of Medicine , Nashville, Tennessee.
Simon D W Frost4 Department of Veterinary Medicine, University of Cambridge , Cambridge, United Kingdom .
Yuhua Ruan1 State Key Laboratory for Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases , Beijing, China .
Sten H Vermund3 Vanderbilt Institute for Global Health, Vanderbilt University School of Medicine , Nashville, Tennessee.
Yiming Shao1 State Key Laboratory for Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases , Beijing, China .
Hui Xing1 State Key Laboratory for Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases , Beijing, China .
Beijing Center for Disease Prevention and Control · CNUniversity of Cambridge · GB

Funding

Multi-component HIV Intervention Packages for Chinese MSMR01AI094562 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI QIAN, HAN-ZHU, VERMUND, STEN H. · 2011 to 2014
$2.5M
NIAID NIH HHS R01 AI094562NIAID NIH HHS R01AI094562
6 · The paper itself

Abstract

We report here two novel HIV-1 recombinant forms (CRF01_AE/B) isolated from two HIV-positive male subjects infected through homosexual contact in Beijing, China. Recombination contributes substantially to the genetic diversity of HIV-1, and is likely to occur in populations in which multiple subtypes circulate. Molecular epidemiological studies showed that subtype B, CRF01_AE, and CRF07_BC are currently cocirculating in parallel among men who have sex with men (MSM) in China, providing the opportunity for the emergence of new recombinants. Phylogenetic analysis of near full-length genome (NFLG) sequences showed that the unique recombinant forms (URFs) were composed of gene regions from CRF01_AE and subtype B. The CRF01_AE region of the recombinants clustered together with a previously described cluster 4 lineage of CRF01_AE. The B regions of both the recombinants clustered within the B strains. The two recombinants were quite similar with six breakpoints in common. These data highlight the importance of continuous surveillance of the dynamic change of HIV-1 subtypes and new recombinants among the MSM population.

Indexed as

Genome, ViralRecombination, GeneticChinaGenetic VariationGenomicsHIV-1HIV InfectionsHomosexuality, MaleHumansMalePhylogeny

Identifiers

PMID26058342
PMCPMC4553378
OpenAlexW2229000163

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.