ArticlePaediatric and perinatal epidemiology2015
Pregnancy Hyperglycaemia and Risk of Prenatal and Postpartum Depressive Symptoms.
Article in Paediatric and perinatal epidemiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.
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Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 61 citations in OpenAlex.
- Gestational diabetes and risk of perinatal depression in low- and middle-income countries: a meta-analysis.Frontiers in psychiatry · 2024Pooled it
- Diabetes in Pregnancy and Risk of Antepartum Depression: A Systematic Review and Meta-Analysis of Cohort Studies.International journal of environmental research and public health · 2020Pooled it
- Do glycaemic treatment targets affect the perinatal mental health status of women with gestational diabetes? - Data from the TARGET Trial.BMC pregnancy and childbirth · 2023Trial
- Factors Associated with Risk of Perinatal Depressive Symptoms Among Puerto Rican Women with Hyperglycemia.Maternal and child health journal · 2022Trial
- The risk of postpartum depressive symptoms in immigrant women with recent gestational diabetes mellitus.Diabetic medicine : a journal of the British Diabetic Association · 2026Article
- Association Between Gestational Diabetes Mellitus and Maternal Depression: A Narrative Review.Cureus · 2025Review
- The causal relationship between gestational diabetes mellitus and postpartum depression: A Mendelian randomization study.Journal of diabetes investigation · 2025Article
- Gestational diabetes mellitus and peripartum depression: a longitudinal study of a bidirectional relationship.BMC pregnancy and childbirth · 2024Article
- Effectiveness of interpersonal psychotherapy in comparison to other psychological and pharmacological interventions for reducing depressive symptoms in women diagnosed with postpartum depression in low- and middle-income countries: A systematic review.Campbell systematic reviews · 2024Review
- Prevalence and determinants of perinatal mental disorders in women with gestational diabetes in New Zealand: Findings from a national longitudinal study.Acta obstetricia et gynecologica Scandinavica · 2024Article
- Article
- Maternal Diet Quality and Prenatal Depressive Symptoms: The Moderating Role of Economic Well-Being.Nutrients · 2023Article
- The Bidirectional Relationship between Gestational Diabetes and Depression in Pregnant Women: A Systematic Search and Review.Healthcare (Basel, Switzerland) · 2023Review
- Article
- Cognition, motor symptoms, and glycolipid metabolism in Parkinson's disease with depressive symptoms.Journal of neural transmission (Vienna, Austria : 1996) · 2022Article
- A longitudinal cohort study of gestational diabetes mellitus and perinatal depression.BMC pregnancy and childbirth · 2022Article
- Urinary phthalate and DINCH metabolite concentrations and gradations of maternal glucose intolerance.Environment international · 2022Article
- Prevalence of depressive and anxiety symptoms in women with gestational diabetes: a longitudinal cohort study.Acta diabetologica · 2021Article
- A systematic review and meta-analysis of gestational diabetes mellitus and mental health among BAME populations.EClinicalMedicine · 2021Article
- PROTOCOL: Effectiveness of interpersonal psychotherapy in comparison to other psychological and pharmacological interventions for reducing depressive symptoms in women diagnosed with postpartum depression in low and middle-income countries: A systematic review.Campbell systematic reviews · 2020Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundGlucose dysregulation in pregnancy may affect maternal depressive symptoms during the prenatal and postpartum periods via both physiologic and psychological pathways.
methodsDuring mid-pregnancy, a combination of 50-g 1-h non-fasting glucose challenge test (GCT) and 100-g 3-h fasting oral glucose tolerance test was used to determine pregnancy glycaemic status among women participating in Project Viva: normal glucose tolerance (NGT), isolated hyperglycaemia (IHG), impaired glucose tolerance (IGT) and gestational diabetes mellitus (GDM). Using the Edinburgh Postnatal Depression Scale (EPDS), we assessed depressive symptoms at mid-pregnancy and again at 6 months postpartum. We used logistic regression, adjusted for sociodemographic, anthropometric and lifestyle factors, to estimate the odds of elevated prenatal and postpartum depressive symptoms (EPDS ≥ 13 on 0-30 scale) in relation to GCT glucose levels and GDM status in separate models.
resultsA total of 9.6% of women showed prenatal and 8.4% postpartum depressive symptoms. Women with higher GCT glucose levels were at greater odds of elevated prenatal depressive symptoms [multivariable-adjusted odds ratio (OR) per standard deviation (SD) increase in glucose levels (27 mg/dL): 1.25; 95%: 1.07, 1.48]. Compared with NGT women, the association appeared stronger among women with IHG [OR: 1.80; 95% confidence interval (CI): 1.08, 3.00] than among those with GDM (OR: 1.45; 95% CI: 0.72, 2.91) or IGT (OR: 1.43; 95% CI: 0.59, 3.46). Neither glucose levels assessed from the GCT nor pregnancy glycaemic status were significantly associated with elevated postpartum depressive symptoms.
conclusionPregnancy hyperglycaemia was cross-sectionally associated with higher risk of prenatal depressive symptoms, but not with postpartum depressive symptoms.
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