Evidence map›Paper›PMID 26057714›Full record

ArticleTherapeutic hypothermia and temperature management2015

Prolonged Local Hypothermia Has No Long-Term Adverse Effect on the Spinal Cord.

Ashwati Vipin, Jukka Kortelainen, Hasan Al-Nashash, Soo Min Chua, Xinyuan Thow, Janani Manivannan, Astrid, Nitish V Thakor, Candace L Kerr, Angelo H All

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PubMed Full text at PMC Publisher
In one paragraph

Article in Therapeutic hypothermia and temperature management, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 13 citations in OpenAlex.

  1. Biomaterials and cell-based therapy post spinal cord injury.Journal of translational medicine · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 4 countries.

Ashwati Vipin1 Singapore Institute for Neurotechnology, National University of Singapore , Singapore, Singapore .
Jukka Kortelainen2 Biomedical Engineering Research Group, Department of Computer Science and Engineering, University of Oulu , Oulu, Finland .
Hasan Al-Nashash3 Department of Electrical Engineering, American University of Sharjah , Sharjah, United Arab Emirates .
Soo Min Chua1 Singapore Institute for Neurotechnology, National University of Singapore , Singapore, Singapore .
Xinyuan Thow1 Singapore Institute for Neurotechnology, National University of Singapore , Singapore, Singapore .
Janani Manivannan4 Department of Orthopedic Surgery, National University of Singapore , Singapore, Singapore .
Astrid1 Singapore Institute for Neurotechnology, National University of Singapore , Singapore, Singapore .
Nitish V Thakor1 Singapore Institute for Neurotechnology, National University of Singapore , Singapore, Singapore .
Candace L Kerr6 Department of Biochemistry and Molecular Biology, University of Maryland , Baltimore, Maryland.
Angelo H All1 Singapore Institute for Neurotechnology, National University of Singapore , Singapore, Singapore .
National University of Singapore · SGJohns Hopkins University · USAmerican University of Sharjah · AEUniversity of Maryland, Baltimore · USUniversity of Oulu · FI

Funding

Consequences of Cardiac Arrest: Brain InjuryR01HL071568 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI GEOCADIN, ROMERGRYKO, THAKOR, NITISH VYOMESH · 2003 to 2022
$8.4M
NHLBI NIH HHS 5R01HL071568
6 · The paper itself

Abstract

Hypothermia is known to be neuroprotective and is one of the most effective and promising first-line treatments for central nervous system (CNS) trauma. At present, induction of local hypothermia, as opposed to general hypothermia, is more desired because of its ease of application and safety; fewer side effects and an absence of severe complications have been noted. Local hypothermia involves temperature reduction of a small and specific segment of the spinal cord. Our group has previously shown the neuroprotective effect of short-term, acute moderate general hypothermia through improvements in electrophysiological and motor behavioral assessments, as well as histological examination following contusive spinal cord injury (SCI) in rats. We have also shown the benefit of using short-term local hypothermia versus short-term general hypothermia post-acute SCI. The overall neuroprotective benefit of hypothermia can be categorized into three main components: (1) induction modality, general versus local, (2) invasive, semi-invasive or noninvasive, and (3) duration of hypothermia induction. In this study, a series of experiments were designed to investigate the feasibility, long-term safety, as well as eventual complications and side effects of prolonged, semi-invasive, moderate local hypothermia (30°C±0.5°C for 5 and 8 hours) in rats with uninjured spinal cord while maintaining their core temperature at 37°C±0.5°C. The weekly somatosensory evoked potential and motor behavioral (Basso, Beattie and Bresnahan) assessments of rats that underwent 5 and 8 hours of semi-invasive local hypothermia, which revealed no statistically significant changes in electrical conductivity and behavioral outcomes. In addition, 4 weeks after local hypothermia induction, histological examination showed no anatomical damages or morphological changes in their spinal cord structure and parenchyma. We concluded that this method of prolonged local hypothermia is feasible, safe, and has the potential for clinical translation.

Indexed as

Central Nervous SystemHypothermia, InducedNeuroprotectionSpinal Cord InjuriesAnimalsBody TemperatureDisease Models, AnimalEvoked Potentials, SomatosensoryFemaleLong Term Adverse EffectsMonitoring, PhysiologicMotor ActivityRatsRats, Sprague-DawleyTime Factors

Identifiers

PMID26057714
PMCPMC4575528
OpenAlexW1466084089

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.