Evidence map›Paper›PMID 26057701›Full record

ArticleACS nano2015

Engineered Nanostructures of Haptens Lead to Unexpected Formation of Membrane Nanotubes Connecting Rat Basophilic Leukemia Cells.

Jie-Ren Li, Shailise S Ross, Yang Liu, Ying X Liu, Kang-Hsin Wang, Huan-Yuan Chen, Fu-Tong Liu, Ted A Laurence, Gang-Yu Liu

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS nano, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Jie-Ren Li†Department of Chemistry, University of California, Davis, California 95616, United States.
Shailise S Ross†Department of Chemistry, University of California, Davis, California 95616, United States.
Yang Liu†Department of Chemistry, University of California, Davis, California 95616, United States.
Ying X Liu†Department of Chemistry, University of California, Davis, California 95616, United States.
Kang-Hsin Wang†Department of Chemistry, University of California, Davis, California 95616, United States.
Huan-Yuan Chen‡Department of Dermatology, School of Medicine, University of California, Davis, Sacramento, California 95817, United States.
Fu-Tong Liu‡Department of Dermatology, School of Medicine, University of California, Davis, Sacramento, California 95817, United States.
Ted A Laurence∥Lawrence Livermore National Laboratory, Livermore, California 94550, United States.
Gang-Yu Liu†Department of Chemistry, University of California, Davis, California 95616, United States.
University of California, Davis · USLawrence Livermore National Laboratory · US

Funding

Galectin-3 in regulation of allergic skin inflammationR01AR056343 · NIAMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI LIU, FU-TONG · 2010 to 2014
$1.7M
Nanostructures For Engineering Immune Responses of Dendritic CellsR21CA176850 · NCI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI LIU, GANG-YU · 2013 to 2014
$331k
NCI NIH HHS 1R21CA176850-01NCI NIH HHS R21 CA176850NIAMS NIH HHS R01 AR056343
6 · The paper itself

Abstract

A recent finding reports that co-stimulation of the high-affinity immunoglobulin E (IgE) receptor (FcεRI) and the chemokine receptor 1 (CCR1) triggered formation of membrane nanotubes among bone-marrow-derived mast cells. The co-stimulation was attained using corresponding ligands: IgE binding antigen and macrophage inflammatory protein 1α (MIP1 α), respectively. However, this approach failed to trigger formation of nanotubes among rat basophilic leukemia (RBL) cells due to the lack of CCR1 on the cell surface (Int. Immunol. 2010, 22 (2), 113-128). RBL cells are frequently used as a model for mast cells and are best known for antibody-mediated activation via FcεRI. This work reports the successful formation of membrane nanotubes among RBLs using only one stimulus, a hapten of 2,4-dinitrophenyl (DNP) molecules, which are presented as nanostructures with our designed spatial arrangements. This observation underlines the significance of the local presentation of ligands in the context of impacting the cellular signaling cascades. In the case of RBL, certain DNP nanostructures suppress antigen-induced degranulation and facilitate the rearrangement of the cytoskeleton to form nanotubes. These results demonstrate an important scientific concept; engineered nanostructures enable cellular signaling cascades, where current technologies encounter great difficulties. More importantly, nanotechnology offers a new platform to selectively activate and/or inhibit desired cellular signaling cascades.

Indexed as

AnimalsBasophilsCell Line, TumorCell Membrane StructuresHaptensNanostructuresRatsHaptensatomic force microscopy (AFM)haptensmast cellsmembrane nanotubesparticle lithographyrat basophilic leukemia (RBL) cellsscanning electron microscopy (SEM)

Identifiers

PMID26057701
PMCPMC4758354
OpenAlexW2295000514

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.