ArticlePloS one2015
Red Blood Cell Distribution Width as a Pragmatic Marker for Outcome in Pediatric Critical Illness.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03403062 (Prognostic Value of Red Cell Distribution Width), which is not on this map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Prognostic Value of Red Cell Distribution Width (RDW) in Neonatal Sepsis in Patients Admitted at Assiut University Children Hospital.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Red blood cell distribution width as a predictor of mortality in critically ill pediatric patients: a systematic review and meta-analysis.Frontiers in pediatrics · 2025Pooled it
- Early postoperative red cell distribution width is associated with prolonged hospital stay and complications after non-cardiac surgery in neonates.International journal of medical sciences · 2026Article
- Red blood cell distribution width (RDW) as a predictor of multiple organ dysfunction in pediatric critical care: a retrospective study.BMC pediatrics · 2025Article
- Red cell distribution width and clinical outcomes in sepsis patients infected with Escherichia coli using data from MIMIC-IV.European journal of medical research · 2025Article
- Advanced biomarkers for prognostic evaluation of pneumonia severity in pediatric intensive care: focus on novel inflammatory and hematological ratios.Italian journal of pediatrics · 2025Article
- Admission Red Blood Cell Distribution Width and Mean Platelet Volume as Predictors of Mortality in the Pediatric Intensive Care Unit: A Five-Year Single-Center Retrospective Study.Journal of clinical medicine · 2025Article
- Article
- Length of stay and its associated factors in the neonatal intensive care unit of Gadarif Hospital, Eastern Sudan: a retrospective study.BMC pediatrics · 2024Article
- A Meta-analysis of the Utility of Red Cell Distribution Width as a Biomarker to Predict Outcomes in Pediatric Illness (PROSPERO CRD42020208777).Journal of pediatric intensive care · 2024Review
- Article
- Red cell distribution width as a prognostic marker for complications of community-acquired pneumonia in children: a comparison with Proadrenomedullin and Copeptin.BMC pulmonary medicine · 2023Article
- Red blood cell distribution width as a potential inflammatory marker in pediatric osteomyelitis.Proceedings (Baylor University. Medical Center) · 2023Article
- Red Blood Cell Distribution Width and Pediatric Community-Acquired Pneumonia Disease Severity.Hospital pediatrics · 2022Article
- Red cell distribution width as a surrogate marker of haemoglobinopathies in western Kenya.African journal of laboratory medicine · 2022Article
- Mean corpuscular haemoglobin concentration as haematological marker to detect changes in red blood cells in sheep infected with Haemonchus contortus.Veterinary research communications · 2021Article
- Article
- Mean platelet volume and red blood cell distribution width is associated with prognosis in premature neonates with sepsis.Open medicine (Warsaw, Poland) · 2021Article
- Red Cell Distribution Width as a Novel Prognostic Marker in Multiple Clinical Studies.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2020Review
- Usefulness of Red Cell Width Distribution (RDW) in the Assessment of Children with Pulmonary Arterial Hypertension (PAH).Pediatric cardiology · 2019Article
- RBC Distribution Width: Biomarker for Red Cell Dysfunction and Critical Illness Outcome?Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2017Observational
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
backgroundRed cell distribution width (RDW) is a routine laboratory measure associated with poor outcomes in adult critical illness.
objectiveWe determined the utility of RDW as an early pragmatic biomarker for outcome in pediatric critical illness.
methodsWe used multivariable logistic regression to test the association of RDW on the first day of pediatric intensive care unit (PICU) admission with prolonged PICU length of stay (LOS) >48 hours and mortality. The area under the receiver operating characteristic curve (AUROC) for RDW was compared to the Pediatric Index of Mortality (PIM)-2 score.
resultsOver a 13-month period, 596 unique patients had RDW measured on the first day of PICU admission. Sepsis was an effect modifier for LOS >48 hours but not mortality. In sepsis, RDW was not associated with LOS >48 hours. For patients without sepsis, each 1% increase in RDW was associated with 1.17 (95% CI 1.06, 1.30) increased odds of LOS >48 hours. In all patients, RDW was independently associated with PICU mortality (OR 1.25, 95% CI 1.09, 1.43). The AUROC for RDW to predict LOS >48 hours and mortality was 0.61 (95% CI 0.56, 0.66) and 0.65 (95% CI 0.55, 0.75), respectively. Although the AUROC for mortality was comparable to PIM-2 (0.75, 95% CI 0.66, 0.83; p = 0.18), RDW did not increase the discriminative utility when added to PIM-2. Despite the moderate AUROC, RDW <13.4% (upper limit of lower quartile) had 53% risk of LOS >48 hours and 3.3% risk of mortality compared to patients with an RDW >15.7% (lower limit of upper quartile) who had 78% risk of LOS >48 hours and 12.9% risk of mortality (p<0.001 for both outcomes).
conclusionsElevated RDW was associated with outcome in pediatric critical illness and provided similar prognostic information as the more complex PIM-2 severity of illness score. Distinct RDW thresholds best discriminate low- versus high-risk patients.
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