Evidence map›Paper›PMID 26057572›Full record

ArticleScientific reports2015

Potent Paracrine Effects of human induced Pluripotent Stem Cell-derived Mesenchymal Stem Cells Attenuate Doxorubicin-induced Cardiomyopathy.

Yuelin Zhang, Xiaoting Liang, Songyan Liao, Weixin Wang, Junwen Wang, Xiang Li, Yue Ding, Yingmin Liang, Fei Gao, Mo Yang and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers.

0numbers the graph read from it
0cells of the map it votes in
77citing papers in PubMed
6.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

77 citing papers in PubMed, 122 citations in OpenAlex.

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  19. CXCR4Stem cells international · 2022
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17 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 2 countries.

Yuelin ZhangDepartment of Medicine, Li Ka Shing Faculty of Medicine, the University of Hong Kong, Hong Kong.
Xiaoting LiangDepartment of Medicine, Li Ka Shing Faculty of Medicine, the University of Hong Kong, Hong Kong.
Songyan LiaoDepartment of Medicine, Li Ka Shing Faculty of Medicine, the University of Hong Kong, Hong Kong.
Weixin WangDepartment of Biochemistry, Li Ka Shing Faculty of Medicine, the University of Hong Kong, Hong Kong.
Junwen WangDepartment of Biochemistry, Li Ka Shing Faculty of Medicine, the University of Hong Kong, Hong Kong.
Xiang LiDepartment of Medicine, Li Ka Shing Faculty of Medicine, the University of Hong Kong, Hong Kong.
Yue DingDepartment of Ophthalmology, Li Ka Shing Faculty of Medicine, the University of Hong Kong, Hong Kong.
Yingmin LiangDepartment of Medicine, Li Ka Shing Faculty of Medicine, the University of Hong Kong, Hong Kong.
Fei GaoDepartment of Ophthalmology, Li Ka Shing Faculty of Medicine, the University of Hong Kong, Hong Kong.
Mo YangDepartment of Ophthalmology, Li Ka Shing Faculty of Medicine, the University of Hong Kong, Hong Kong.
Qingling FuOtorhinolaryngology Hospital, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Aimin Xu1] Department of Medicine, Li Ka Shing Faculty of Medicine, the University of Hong Kong, Hong Kong [2] Shenzhen Institutes of Research and Innovation, the University of Hong Kong, China.
Yuet-Hung ChaiDepartment of Medicine, Li Ka Shing Faculty of Medicine, the University of Hong Kong, Hong Kong.
Jia HeDepartment of Ophthalmology, Li Ka Shing Faculty of Medicine, the University of Hong Kong, Hong Kong.
Hung-Fat Tse1] Department of Medicine, Li Ka Shing Faculty of Medicine, the University of Hong Kong, Hong Kong [2] Shenzhen Institutes of Research and Innovation, the University of Hong Kong, China.
Qizhou Lian1] Department of Medicine, Li Ka Shing Faculty of Medicine, the University of Hong Kong, Hong Kong [2] Department of Ophthalmology, Li Ka Shing Faculty of Medicine, the University of Hong Kong, Hong Kong [3] Shenzhen Institutes of Research and Innovation, the University of Hong Kong, China.
University of Hong Kong · HKChinese University of Hong Kong · CNCity University of Hong Kong, Shenzhen Research Institute · CNThe First Affiliated Hospital, Sun Yat-sen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Transplantation of bone marrow mesenchymal stem cells (BM-MSCs) can protect cardiomyocytes against anthracycline-induced cardiomyopathy (AIC) through paracrine effects. Nonetheless the paracrine effects of human induced pluripotent stem cell-derived MSCs (iPSC-MSCs) on AIC are poorly understood. In vitro studies reveal that doxorubicin (Dox)-induced reactive oxidative stress (ROS) generation and cell apoptosis in neonatal rat cardiomyocytes (NRCMs) are significantly reduced when treated with conditioned medium harvested from BM-MSCs (BM-MSCs-CdM) or iPSC-MSCs (iPSC-MSCs-CdM). Compared with BM-MSCs-CdM, NRCMs treated with iPSC-MSCs-CdM exhibit significantly less ROS and cell apoptosis in a dose-dependent manner. Transplantation of BM-MSCs-CdM or iPSC-MSCs-CdM into mice with AIC remarkably attenuated left ventricular (LV) dysfunction and dilatation. Compared with BM-MSCs-CdM, iPSC-MSCs-CdM treatment showed better alleviation of heart failure, less cardiomyocyte apoptosis and fibrosis. Analysis of common and distinct cytokines revealed that macrophage migration inhibitory factor (MIF) and growth differentiation factor-15 (GDF-15) were uniquely overpresented in iPSC-MSC-CdM. Immunodepletion of MIF and GDF-15 in iPSC-MSCs-CdM dramatically decreased cardioprotection. Injection of GDF-15/MIF cytokines could partially reverse Dox-induced heart dysfunction. We suggest that the potent paracrine effects of iPSC-MSCs provide novel "cell-free" therapeutic cardioprotection against AIC, and that MIF and GDF-15 in iPSC-MSCs-CdM are critical for these enhanced cardioprotective effects.

Indexed as

Antibiotics, AntineoplasticCardiomyopathiesCulture Media, ConditionedDoxorubicinHumansMesenchymal Stem CellsMesenchymal Stem Cell TransplantationPluripotent Stem CellsAntibiotics, AntineoplasticCulture Media, ConditionedDoxorubicin

Identifiers

PMID26057572
PMCPMC4460911
OpenAlexW1840448288

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.