Evidence map›Paper›PMID 26057450›Full record

ArticleBritish journal of cancer2015

Expression of p16 in squamous cell carcinoma of the mobile tongue is independent of HPV infection despite presence of the HPV-receptor syndecan-1.

N Sgaramella, P J Coates, K Strindlund, L Loljung, G Colella, G Laurell, R Rossiello, L L Muzio, C Loizou, G Tartaro and 4 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in British journal of cancer, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 2 pooled it
6.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 49 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Copy number variation: A prognostic marker for young patients with squamous cell carcinoma of the oral tongue.Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology · 2019
    Article
  16. Article
  17. Article
  18. Article
  19. Increased expression of p16 in both oral and genital lichen planus.Medicina oral, patologia oral y cirugia bucal · 2018
    Article
  20. Evaluation of the budding and depth of invasion (BD) model in oral tongue cancer biopsies.Virchows Archiv : an international journal of pathology · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 7 institutions in 4 countries.

N Sgaramella1] Department of Medical Biosciences, Umeå University, Umeå SE-901 85, Sweden [2] Multidisciplinary Department of Medical, Surgical and Dental Specialties, Second University of Naples, Naples, Italy.
P J CoatesDivision of Medical Sciences, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK.
K StrindlundDepartment of Medical Biosciences, Umeå University, Umeå SE-901 85, Sweden.
L LoljungDepartment of Medical Biosciences, Umeå University, Umeå SE-901 85, Sweden.
G ColellaMultidisciplinary Department of Medical, Surgical and Dental Specialties, Second University of Naples, Naples, Italy.
G LaurellDepartment of Clinical Sciences, ENT, Uppsala University, Uppsala SE-751 05, Sweden.
R RossielloDipartimento Universitario di Anatomia Patologica, Seconda Universita' Degli Studi di Napoli, Piazza Miraglia, Naples 80138, Italy.
L L MuzioDepartment of Clinical and Experimental Medicine, University of Foggia, Foggia 71122, Italy.
C LoizouDepartment of Clinical Sciences, Division of Otorhinolaryngology, Umeå University, Umeå SE-901 85, Sweden.
G TartaroMultidisciplinary Department of Medical, Surgical and Dental Specialties, Second University of Naples, Naples, Italy.
K OlofssonDepartment of Clinical Sciences, Division of Otorhinolaryngology, Umeå University, Umeå SE-901 85, Sweden.
K DanielssonDepartment of Odontology, Umeå University, Umeå SE-90185, Sweden.
R Fåhraeus1] RECAMO, Masaryk Memorial Cancer Institute, Zluty kopec 7, Brno 656 53, Czech Republic [2] University Paris Diderot, INSERM UMRS1162, 27 rue Juliette Dodu, Paris 75010, France.
K NylanderDepartment of Medical Biosciences, Umeå University, Umeå SE-901 85, Sweden.
Umeå University · SEUniversity of Naples Federico II · ITMasaryk Memorial Cancer Institute · CZNinewells Hospital · GBUniversity of Campania "Luigi Vanvitelli" · ITUniversity of Foggia · ITUppsala University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTongue squamous cell carcinoma (TSCC) is increasing in incidence, especially among young patients and preferably females. Infection with human papilloma virus (HPV) has been suggested as a cause of SCC in the head and neck, and the proportion of oropharyngeal cancers caused by HPV has steadily increased.

methodsSamples from 109 patients with primary TSCC were analysed for the presence of HPV16 by in situ hybridisation and for expression of its surrogate marker p16 and the HPV receptor syndecan-1 by immunhistochemistry.

resultsNo evidence of HPV16 DNA was observed in the tumours, although one-third showed p16 staining. There was no difference in the expression of the primary HPV receptor, syndecan-1, between TSCC and a group of tonsil SCC.

conclusionWhereas p16 is expressed in some TSCCs, HPV16 is undetectable, therefore, p16 cannot be used as a surrogate marker for high-risk HPV-infection in this tumour. Despite presence of the HPV-receptor syndecan-1 in TSCC, HPV prefers the tonsillar environment. Lack of p16 associates with worse prognosis primarily in patients aged ⩽40 years with tongue SCC. The improved prognosis seen in p16-positive TSCC can be due to induction of a senescent phenotype or an inherent radiosensitivity due to the ability of p16 to inhibit homologous recombination repair.

Indexed as

AdultAgedAged, 80 and overCarcinoma, Squamous CellCyclin-Dependent Kinase Inhibitor p16DNA, ViralFemaleHead and Neck NeoplasmsHuman papillomavirus 16HumansIn Situ HybridizationMaleMiddle AgedNeoplasm ProteinsPapillomavirus InfectionsReceptors, VirusCDKN2A protein, humanCyclin-Dependent Kinase Inhibitor p16DNA, ViralNeoplasm ProteinsReceptors, VirusSyndecan-1

Identifiers

PMID26057450
PMCPMC4506391
OpenAlexW2149143897

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.