Evidence map›Paper›PMID 26057099›Full record

ReviewCurrent opinion in structural biology2015

The chromatin fiber: multiscale problems and approaches.

Gungor Ozer, Antoni Luque, Tamar Schlick

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current opinion in structural biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 78 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Understanding and Simulating the Dynamics of a Polymer-Like Chromatin.Methods in molecular biology (Clifton, N.J.) · 2025
    Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
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  17. Article
  18. A MULTISCALE VISION-ILLUSTRATIVE APPLICATIONS FROM BIOLOGY TO ENGINEERING.International journal for multiscale computational engineering · 2021
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 2 countries.

Gungor OzerDepartment of Chemistry, 100 Washington Square East, New York University, New York, NY 10003, USA.
Antoni LuqueDepartment of Chemistry, 100 Washington Square East, New York University, New York, NY 10003, USA; Current address: Department of Mathematics & Statistics and Viral Information Institute, San Diego State University, 5500 Campanile Drive, San Diego, CA 92182-7720, USA.
Tamar SchlickDepartment of Chemistry, 100 Washington Square East, New York University, New York, NY 10003, USA; Courant Institute of Mathematical Sciences, New York University, 251 Mercer Street, New York, NY 10012, USA; NYU-ECNU Center for Computational Chemistry at NYU Shanghai, 3663 Zhongshan Road North, Shanghai 200062, China. Electronic address: schlick@nyu.edu.
New York University · USNew York University Shanghai · CNSan Diego State University · US

Funding

Modeling Chromatin Organization and FunctionR01GM055164 · NIGMS · NEW YORK UNIVERSITY · PI SCHLICK, TAMAR · 1998 to 2015
$2.6M
NIGMS NIH HHS R01 GM055164NIGMS NIH HHS R01 GM55164
6 · The paper itself

Abstract

The structure of chromatin, affected by many factors from DNA linker lengths to posttranslational modifications, is crucial to the regulation of eukaryotic cells. Combined experimental and computational methods have led to new insights into its structural and dynamical features, from interactions due to the flexible core histone tails or linker histones to the physical mechanism driving the formation of chromosomal domains. Here we present a perspective of recent advances in chromatin modeling techniques at the atomic, mesoscopic, and chromosomal scales with a view toward developing multiscale computational strategies to integrate such findings. Innovative modeling methods that connect molecular to chromosomal scales are crucial for interpreting experiments and eventually deciphering the complex dynamic organization and function of chromatin in the cell.

Indexed as

ChromatinModels, MolecularAnimalsHumansNucleosomesPolymerizationChromatinNucleosomes

Identifiers

PMID26057099
PMCPMC4476956
OpenAlexW604319760

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.