Evidence map›Paper›PMID 26057017›Full record

ArticleBioconjugate chemistry2015

Sulfonated Polyethylenimine for Photosensitizer Conjugation and Targeting.

Upendra Chitgupi, Yumiao Zhang, Chi Y Lo, Shuai Shao, Wentao Song, Jumin Geng, Sriram Neelamegham, Jonathan F Lovell

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioconjugate chemistry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.4field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Upendra Chitgupi†Department of Biomedical Engineering and ‡Department of Chemical and Biological Engineering, University at Buffalo, State University of New York, Buffalo, New York 14260, United States.
Yumiao Zhang†Department of Biomedical Engineering and ‡Department of Chemical and Biological Engineering, University at Buffalo, State University of New York, Buffalo, New York 14260, United States.
Chi Y Lo†Department of Biomedical Engineering and ‡Department of Chemical and Biological Engineering, University at Buffalo, State University of New York, Buffalo, New York 14260, United States.
Shuai Shao†Department of Biomedical Engineering and ‡Department of Chemical and Biological Engineering, University at Buffalo, State University of New York, Buffalo, New York 14260, United States.
Wentao Song†Department of Biomedical Engineering and ‡Department of Chemical and Biological Engineering, University at Buffalo, State University of New York, Buffalo, New York 14260, United States.
Jumin Geng†Department of Biomedical Engineering and ‡Department of Chemical and Biological Engineering, University at Buffalo, State University of New York, Buffalo, New York 14260, United States.
Sriram Neelamegham†Department of Biomedical Engineering and ‡Department of Chemical and Biological Engineering, University at Buffalo, State University of New York, Buffalo, New York 14260, United States.
Jonathan F Lovell†Department of Biomedical Engineering and ‡Department of Chemical and Biological Engineering, University at Buffalo, State University of New York, Buffalo, New York 14260, United States.
University at Buffalo, State University of New York · US

Funding

Systems Biology of GlycosylationR01HL103411 · NHLBI · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI NEELAMEGHAM, SRIRAM · 2011 to 2025
$7.1M
Targeting Tumors with Resealable Nanovesicles Permeabilized by NIR LightDP5OD017898 · OD · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI LOVELL, JONATHAN F · 2013 to 2017
$1.9M
Anesthesiology Research Training ProgramT32GM099607 · NIGMS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI KNIGHT III, PAUL R · 2012 to 2021
$1.8M
NHLBI NIH HHS HL103411NHLBI NIH HHS R01 HL103411NIGMS NIH HHS T32 GM099607NIH HHS DP5 OD017898NIH HHS DP5OD017898
6 · The paper itself

Abstract

Polysulfonated macromolecules are known to bind selectins, adhesion membrane proteins which are broadly implicated in inflammation. Commercially available branched polyethylenimine (PEI) was reacted with chlorosulfonic acid to generate sulfonated PEI with varying degrees of sulfonation. Remaining unreacted amine groups were then used for straightforward conjugation with pyropheophoribide-a, a near-infrared photosensitizer. Photosensitizer-labeled sulfonated PEI conjugates inhibited blood coagulation and were demonstrated to specifically bind to cells genetically programmed to overexpress L-selectin (CD62L) or P-selectin (CD62P). In vitro, following targeting, selectin-expressing cells could be destroyed via photodynamic therapy.

Indexed as

PhotochemotherapyAnimalsBlood CoagulationCell SurvivalCHO CellsCricetulusGenetic TherapyL-SelectinMiceMice, Inbred ICRPhotosensitizing AgentsPolyethyleneiminePolymersP-SelectinSulfonic AcidsL-SelectinPhotosensitizing AgentsPolyethyleneiminePolymersP-SelectinSulfonic Acids

Identifiers

PMID26057017
PMCPMC4651968
OpenAlexW2516027401

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.