Evidence map›Paper›PMID 26056951›Full record

ReviewCurrent opinion in chemical biology2015

Synthetic biology expands chemical control of microorganisms.

Tyler J Ford, Pamela A Silver

Abstract readReview
In one paragraph

Review in Current opinion in chemical biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Article
  6. Article
  7. Proceedings of the 7th ACM International Conference on Nanoscale Computing and Communication : Virtual Conference, September 23-25, 2020 : NanoCom 2020. ACM International Conference on Nanoscale Computing and Communication (7th : 2020 :... · 2020
    Article
  8. Article
  9. Article
  10. Review
  11. Performing selections under dynamic conditions for synthetic biology applications.Integrative biology : quantitative biosciences from nano to macro · 2016
    Article
  12. Article
  13. Design of a bistable switch to control cellular uptake.Journal of the Royal Society, Interface · 2015
    Article
  14. Article
  15. Biocatalysis for the application of CO2 as a chemical feedstock.Beilstein journal of organic chemistry · 2015
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Tyler J FordDepartment of Systems Biology, Harvard Medical School, Boston, MA 02115, USA.
Pamela A SilverDepartment of Systems Biology, Harvard Medical School, Boston, MA 02115, USA; Wyss Institute for Biologically Inspired Engineering, Harvard Medical School, Boston, MA 02115, USA. Electronic address: pamela_silver@hms.harvard.edu.

Funding

HARVARD CLINICAL AND TRANSLATIONAL SCIENCE CENTER (UL1)UL1RR025758 · NCRR · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2008 to 2011
$91.4M
NCRR NIH HHS UL1 RR025758
6 · The paper itself

Abstract

The tools of synthetic biology allow researchers to change the ways engineered organisms respond to chemical stimuli. Decades of basic biology research and new efforts in computational protein and RNA design have led to the development of small molecule sensors that can be used to alter organism function. These new functions leap beyond the natural propensities of the engineered organisms. They can range from simple fluorescence or growth reporting to pathogen killing, and can involve metabolic coordination among multiple cells or organisms. Herein, we discuss how synthetic biology alters microorganisms' responses to chemical stimuli resulting in the development of microbes as toxicity sensors, disease treatments, and chemical factories.

Indexed as

AnimalsBacteriaBacterial InfectionsBiosensing TechniquesBiotechnologyGenetic EngineeringHumansMetabolic Networks and PathwaysQuorum SensingSynthetic Biology

Identifiers

PMID26056951
PMCPMC4961477

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.