ArticleMolecular and cellular therapies2014
Low pH of interstitial fluid around hippocampus of the brain in diabetic OLETF rats.
Article in Molecular and cellular therapies, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 29 citations in OpenAlex.
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- The Effects of Systemic and Local Acidosis on Insulin Resistance and Signaling.International journal of molecular sciences · 2018Review
- The Proposal of Molecular Mechanisms of Weak Organic Acids Intake-Induced Improvement of Insulin Resistance in Diabetes Mellitus via Elevation of Interstitial Fluid pH.International journal of molecular sciences · 2018Review
- Improvement of Diabetes Mellitus Symptoms by Intake of Ninjin'yoeito.Frontiers in nutrition · 2018Article
- Actions of Quercetin, a Polyphenol, on Blood Pressure.Molecules (Basel, Switzerland) · 2017Review
- Effect of Brazilian green propolis in patients with type 2 diabetes: A double-blind randomized placebo-controlled study.Biomedical reports · 2015Article
- Roles of interstitial fluid pH in diabetes mellitus: Glycolysis and mitochondrial function.World journal of diabetes · 2015Review
- Significance of propolis administration for homeostasis of CD4(+)CD25(+) immunoregulatory T cells controlling hyperglycemia.SpringerPlus · 2014Article
- Importance of pH homeostasis in metabolic health and diseases: crucial role of membrane proton transport.BioMed research international · 2014Review
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWe have reported that pH values of ascites and interstitial fluids around the liver in Otsuka Long-Evans Tokushima Fatty (OLETF) rats are significantly lower than normal pH, 7.40, of mammalian body fluids (Biochem Biophys Res Commun 2013, 432:650), and that this lowered pH of interstitial fluid causes the insulin resistance in diabetic patients by decreasing insulin-binding to its receptors (J Physiol Sci 2013, 63:S199). In the preset study, we tried to measure the interstitial fluid pH in diabetic OLETF rats, since the interstitial fluid pH plays key factors in the brain function from a viewpoint of the binding affinity of neurotransmitters to their receptors.
findingsWe found that the pH value of interstitial fluids around hippocampus, the most important area for memory, in diabetic OLETF rats was lower than that in normal rats by measuring pH with antimony pH electrodes.
conclusionsThe lowered pH of interstitial fluid around hippocampus of the brain in diabetic rats observed in the present study suggests that the function of hippocampus of the brain would be diminished due to low affinity of various types of neurotransmitters, playing key roles in the hippocampus function, to their receptors. Therefore, we indicate that maintenance of the interstitial fluid pH at the normal level would be one of the most important key factors for molecular and cellular therapies in various types of diseases including diabetes mellitus.
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Identifiers
26056575PMC4452057W2143563230What OpenQuestion holds
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