ArticleCell & bioscience2015
Quantitative proteomic analysis of single or fractionated radiation-induced proteins in human breast cancer MDA-MB-231 cells.
Article in Cell & bioscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 24 citations in OpenAlex.
- Deciphering Radiotherapy Resistance: A Proteomic Perspective.Proteomes · 2025Review
- Gelsolin knockdown confers radiosensitivity to glioblastoma cells.Cancer medicine · 2024Article
- A Review of Radiation-Induced Alterations of Multi-Omic Profiles, Radiation Injury Biomarkers, and Countermeasures.Radiation research · 2023Review
- Article
- -Omics potential of in vitro skin models for radiation exposure.Cellular and molecular life sciences : CMLS · 2022Review
- Application of Proteomics in the Discovery of Radiosensitive Cancer Biomarkers.Frontiers in oncology · 2022Review
- Activated ERK Signaling Is One of the Major Hub Signals Related to the Acquisition of Radiotherapy-Resistant MDA-MB-231 Breast Cancer Cells.International journal of molecular sciences · 2021Article
- Quantitative proteomic analysis reveals AK2 as potential biomarker for late normal tissue radiotoxicity.Radiation oncology (London, England) · 2019Article
- Radiation Therapy in Patients With Brain Cancer: Post-proteomics Interpretation.Journal of lasers in medical sciences · 2019Article
- Assessment of the SRC Inhibition Role in the Efficacy of Breast Cancer Radiotherapy.Journal of lasers in medical sciences · 2019Review
- Comprehensive Analysis of Cancer-Proteogenome to Identify Biomarkers for the Early Diagnosis and Prognosis of Cancer.Proteomes · 2017Review
- Gelsolin Promotes Radioresistance in Non-Small Cell Lung Cancer Cells Through Activation of Phosphoinositide 3-Kinase/Akt Signaling.Technology in cancer research & treatment · 2017Article
- The proteome signature of the inflammatory breast cancer plasma membrane identifies novel molecular markers of disease.American journal of cancer research · 2016Article
- Modulation of dendritic cell function by the radiation-mediated secretory protein γ-synuclein.Cell death discovery · 2015Article
- A Quantitative Proteomic Analysis of Urine from Gamma-Irradiated Non-Human Primates.Journal of proteomics & bioinformaticsArticle
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRadiotherapy is widely used to treat cancer alone or in combination with surgery, chemotherapy, and immunotherapy. However, damage to normal tissues and radioresistance of tumor cells are major obstacles to successful radiotherapy. Furthermore, the immune network around tumors appears to be connected to tumor progression and recurrence.
methodsWe investigated the cytosolic proteins produced by irradiated tumor cells by using a quantitative proteomic approach based on stable isotope labeling by amino acids in cell culture. MDA-MB-231 breast cancer cells were treated with a single or fractionated 10 Gray dose of (137)Cs γ-radiation, which was selected based on cell viability.
resultsRadiation-induced proteins were differentially expressed based on the fractionated times of radiation and were involved in multiple biological functions, including energy metabolism and cytoskeleton organization. We identified 46 proteins increased by at least 1.3-fold, and high ranks were determined for cathepsin D, gelsolin, arginino-succinate synthase 1, peroxiredoxin 5, and C-type mannose receptor 2.
conclusionThese results suggest that a number of tumor-derived factors upregulated by γ-radiation are promising targets for modulation of the immune response during radiation treatment.
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