Evidence map›Paper›PMID 26056451›Full record

ArticleNeuropsychiatric disease and treatment2015

Evaluation of acute cardiovascular effects of immediate-release methylphenidate in children and adolescents with attention-deficit hyperactivity disorder.

Marco Lamberti, Domenico Italiano, Laura Guerriero, Gessica D'Amico, Rosamaria Siracusano, Massimo Ingrassia, Eva Germanò, Maria Pia Calabrò, Edoardo Spina, Antonella Gagliano

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In one paragraph

Article in Neuropsychiatric disease and treatment, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Marco LambertiDivision of Child Neurology and Psychiatry, Department of Pediatrics, University of Messina, Messina, Italy ; Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy.
Domenico ItalianoDepartment of Clinical and Experimental Medicine, University of Messina, Messina, Italy.
Laura GuerrieroDivision of Child Neurology and Psychiatry, Department of Pediatrics, University of Messina, Messina, Italy.
Gessica D'AmicoDivision of Pediatric Cardiology, Department of Pediatrics, University of Messina, Messina, Italy.
Rosamaria SiracusanoDivision of Child Neurology and Psychiatry, Department of Pediatrics, University of Messina, Messina, Italy ; Institution of Clinical Physiology, CNR, Pisa, Italy.
Massimo IngrassiaDivision of Psychology, Department of Humanities and Social Sciences, University of Messina, Messina, Italy.
Eva GermanòDivision of Child Neurology and Psychiatry, Department of Pediatrics, University of Messina, Messina, Italy.
Maria Pia CalabròDivision of Pediatric Cardiology, Department of Pediatrics, University of Messina, Messina, Italy.
Edoardo SpinaDepartment of Clinical and Experimental Medicine, University of Messina, Messina, Italy.
Antonella GaglianoDivision of Child Neurology and Psychiatry, Department of Pediatrics, University of Messina, Messina, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Attention-deficit hyperactivity disorder is a frequent condition in children and often extends into adulthood. Use of immediate-release methylphenidate (MPH) has raised concerns about potential cardiovascular adverse effects within a few hours after administration. This study was carried out to investigate acute effects of MPH on electrocardiogram (ECG) in a pediatric population. A total of 54 consecutive patients with attention-deficit hyperactivity disorder (51 males and 3 females; mean age =12.14±2.6 years, range 6-19 years), receiving a new prescription of MPH, underwent a standard ECG 2 hours before and after the administration of MPH 10 mg per os. Basal and posttreatment ECG parameters, including mean QT (QT interval when corrected for heart rate [QTc]), QTc dispersion (QTd) interval duration, T-peak to T-end (TpTe) intervals, and TpTe/QT ratio were compared. Significant modifications of both QTc and QTd values were not found after drug administration. QTd fluctuated slightly from 25.7±9.3 milliseconds to 25.1±8.4 milliseconds; QTc varied from 407.6±12.4 milliseconds to 409.8±12.7 milliseconds. A significant variation in blood pressure (systolic blood pressure 105.4±10.3 vs 109.6±11.5; P<0.05; diastolic blood pressure 59.2±7.1 vs 63.1±7.9; P<0.05) was observed, but all the data were within normal range. Heart rate moved from 80.5±15.5 bpm to 87.7±18.8 bpm. No change in TpTe values was found, but a statistically significant increase in TpTe/QTc intervals was found with respect to basal values (0.207±0.02 milliseconds vs 0.214±0.02 milliseconds; P<0.01). The findings of this study show no significant changes in ECG parameters. TpTe values can be an additional parameter to evaluate borderline cases.

Indexed as

ADHDadolescentscardiovascular effectschildrenmethylphenidate

Identifiers

PMID26056451
PMCPMC4431494

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.