ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences2015
Common cancer in a wild animal: the California sea lion (Zalophus californianus) as an emerging model for carcinogenesis.
Review in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 58 citations in OpenAlex.
- Inflammatory Pseudotumour in Common Seal (Phoca vitulina): A Case Report.Veterinary medicine and science · 2026Article
- Cross-Species Exome Sequencing Reveals Recurrent Genomic Alterations in California Sea Lion (Genes · 2026Article
- The complex effects of modern oncogenic environments on the fitness, evolution and conservation of wildlife species.Evolutionary applications · 2024Article
- Bridging clinic and wildlife care with AI-powered pan-species computational pathology.Nature communications · 2023Article
- A Coupled Human and Natural Systems Framework to Characterize Emerging Infectious Diseases-The Case of Fibropapillomatosis in Marine Turtles.Animals : an open access journal from MDPI · 2023Review
- The One Medicine concept: its emergence from history as a systematic approach to re-integrate human and veterinary medicine.Emerging topics in life sciences · 2021Review
- Sea Turtles in the Cancer Risk Landscape: A Global Meta-Analysis of Fibropapillomatosis Prevalence and Associated Risk Factors.Pathogens (Basel, Switzerland) · 2021Article
- Hi-C scaffolded short- and long-read genome assemblies of the California sea lion are broadly consistent for syntenic inference across 45 million years of evolution.Molecular ecology resources · 2021Article
- Unlocking the Role of a Genital Herpesvirus, Otarine Herpesvirus 1, in California Sea Lion Cervical Cancer.Animals : an open access journal from MDPI · 2021Article
- What Animal Cancers teach us about Human Biology.Theranostics · 2021Review
- Comparative Oncology: New Insights into an Ancient Disease.iScience · 2020Review
- The ecology and evolution of wildlife cancers: Applications for management and conservation.Evolutionary applications · 2020Article
- Accuracy and precision of age determination using growth layer groups for California sea lions (Marine Mammal Science · 2019Article
- Metastasis in the wild: investigating metastasis in non-laboratory animals.Clinical & experimental metastasis · 2019Review
- Cancer in wildlife: patterns of emergence.Nature reviews. Cancer · 2018Review
- Genetic diversity, inbreeding and cancer.Proceedings. Biological sciences · 2018Review
- No evidence for clonal transmission of urogenital carcinoma in California sea lions (Wellcome open research · 2017Article
- Transformation of the genital epithelial tract occurs early in California sea lion development.Royal Society open science · 2016Article
- Sentinel California sea lions provide insight into legacy organochlorine exposure trends and their association with cancer and infectious disease.One health (Amsterdam, Netherlands) · 2015Article
- Peto's paradox and the promise of comparative oncology.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Naturally occurring cancers in non-laboratory species have great potential in helping to decipher the often complex causes of neoplasia. Wild animal models could add substantially to our understanding of carcinogenesis, particularly of genetic and environmental interactions, but they are currently underutilized. Studying neoplasia in wild animals is difficult and especially challenging in marine mammals owing to their inaccessibility, lack of exposure history, and ethical, logistical and legal limits on experimentation. Despite this, California sea lions (Zalophus californianus) offer an opportunity to investigate risk factors for neoplasia development that have implications for terrestrial mammals and humans who share much of their environment and diet. A relatively accessible California sea lion population on the west coast of the USA has a high prevalence of urogenital carcinoma and is regularly sampled during veterinary care in wildlife rehabilitation centres. Collaborative studies have revealed that genotype, persistent organic pollutants and a herpesvirus are all associated with this cancer. This paper reviews research to date on the epidemiology and pathogenesis of urogenital carcinoma in this species, and presents the California sea lion as an important and currently underexploited wild animal model of carcinogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.