ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences2015
Maternal-fetal conflict, genomic imprinting and mammalian vulnerabilities to cancer.
Review in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluation of Genomic Imprinting Testing for Detection and Surveillance of Bladder Cancer Patients
Role of Genomic Imprinting in Cancer Diagnosis
Who cites it
22 citing papers in PubMed.
- Challenges and emerging strategies for genome-wide evaluation of loss of imprinting in cancer.British journal of biomedical science · 2026Review
- Evidence for coopetition at the maternal-fetal interface shaping placental invasion.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Non-disruptive 3D profiling of combinations of epigenetic marks in single cells.bioRxiv : the preprint server for biology · 2025Article
- Brinkmanship in intragenomic conflict.Proceedings. Biological sciences · 2025Article
- The duality of microchimerism and cancer in parous women: a review and evolutionary perspective.Seminars in immunopathology · 2025Review
- Cancer Prevalence across Vertebrates.Cancer discovery · 2025Article
- Review
- An evolutionary perspective on the association between grandmother-mother relationships and maternal mental health among a cohort of pregnant Latina women.Evolution and human behavior : official journal of the Human Behavior and Evolution Society · 2023Article
- Uniparental disomy is a chromosomic disorder in the first place.Molecular cytogenetics · 2022Article
- Transposable elements shape the evolution of mammalian development.Nature reviews. Genetics · 2021Review
- The Dynamic Changes of Transcription Factors During the Development Processes of Human Biparental and Uniparental Embryos.Frontiers in cell and developmental biology · 2021Article
- Comparative Oncology: New Insights into an Ancient Disease.iScience · 2020Review
- Comment on the exchange between BoddyEvolution, medicine, and public health · 2020Article
- Lifetime cancer prevalence and life history traits in mammals.Evolution, medicine, and public health · 2020Article
- From humans to hydra: patterns of cancer across the tree of life.Biological reviews of the Cambridge Philosophical Society · 2018Review
- Short- and long-term evolution in our arms race with cancer: Why the war on cancer is winnable.Evolutionary applications · 2018Article
- Cancer cell transmission via the placenta.Evolution, medicine, and public health · 2018Review
- Lost in translation: The 3'-UTR ofEvolution, medicine, and public health · 2018Article
- Explaining the futility of the reproductive process in humans: past, present, and future.Journal of assisted reproduction and genetics · 2017Article
- Allele-specific wild-type TP53 expression in the unaffected carrier parent of children with Li-Fraumeni syndrome.Cancer genetics · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Antagonistic coevolution between maternal and fetal genes, and between maternally and paternally derived genes may have increased mammalian vulnerability to cancer. Placental trophoblast has evolved to invade maternal tissues and evade structural and immunological constraints on its invasion. These adaptations can be co-opted by cancer in intrasomatic selection. Imprinted genes of maternal and paternal origin favour different degrees of proliferation of particular cell types in which they reside. As a result, the set of genes favouring greater proliferation will be selected to evade controls on cell-cycle progression imposed by the set of genes favouring lesser proliferation. The dynamics of stem cell populations will be a particular focus of this intragenomic conflict. Gene networks that are battlegrounds of intragenomic conflict are expected to be less robust than networks that evolve in the absence of conflict. By these processes, maternal-fetal and intragenomic conflicts may undermine evolved defences against cancer.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.