Evidence map›Paper›PMID 26056358›Full record

ArticlePhilosophical transactions of the Royal Society of London. Series B, Biological sciences2015

Inclusive fitness effects can select for cancer suppression into old age.

Joel S Brown, C Athena Aktipis

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Review
  2. Article
  3. The Elephant and the Spandrel.Evolution, medicine, and public health · 2025
    Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Is adaptive therapy natural?PLoS biology · 2018
    Article
  10. From humans to hydra: patterns of cancer across the tree of life.Biological reviews of the Cambridge Philosophical Society · 2018
    Review
  11. Article
  12. Article
  13. Peto's paradox and the promise of comparative oncology.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015
    Article
  14. The multiple facets of Peto's paradox: a life-history model for the evolution of cancer suppression.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015
    Article
  15. Peto's paradox and the hallmarks of cancer: constructing an evolutionary framework for understanding the incidence of cancer.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Joel S BrownDepartment of Biological Sciences, Cancer Center, University of Illinois at Chicago, Chicago, IL 60612, USA Cancer Biology and Evolution Program, Moffitt Cancer Center, Tampa, FL 33612, USA.
C Athena AktipisDepartment of Psychology, Center for Social Dynamics and Complexity, Center for Evolution and Medicine, Arizona State University, Tempe, AZ 85287-4501, USA Center for Evolution and Cancer, University of California San Francisco, San Francisco, CA 94143, USA aktipis@asu.edu.

Funding

The Physi(ologi)cal Microenvironment and its Role in Tumor Invasion and MetastaseU54CA143970 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI GATENBY, ROBERT A · 2009 to 2014
$9.3M
Application of Evolutionary Principles to Maintain Cancer Control (PQ21)R01CA170595 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI GATENBY, ROBERT A · 2012 to 2015
$2.1M
NCI NIH HHS 1U54 CA143970-01NCI NIH HHS R01 CA170595
6 · The paper itself

Abstract

Natural selection can favour health at youth or middle age (high reproductive value) over health at old age (low reproductive value). This means, all else being equal, selection for cancer suppression should dramatically drop after reproductive age. However, in species with significant parental investment, the capacity to enhance inclusive fitness may increase the reproductive value of older individuals or even those past reproductive age. Variation in parental investment levels could therefore contribute to variation in cancer susceptibility across species. In this article, we describe a simple model and framework for the evolution of cancer suppression with varying levels of parental investment and use this model to make testable predictions about variation in cancer suppression across species. This model can be extended to show that selection for cancer suppression is stronger in species with cooperative breeding systems and intergenerational transfers. We consider three cases that can select for cancer suppression into old age: (i) extended parental care that increases the survivorship of their offspring, (ii) grandparents contributing to higher fecundity of their children and (iii) cooperative breeding where helpers forgo reproduction or even survivorship to assist parents in having higher fecundity.

Indexed as

Models, BiologicalAgingAnimalsBiological EvolutionBreedingCooperative BehaviorFemaleFertilityGenetic FitnessHumansMaleNeoplasmsReproductionSelection, Geneticcooperative breedinggrandparentinginclusive fitnessintergenerational transfersparental investmentPeto's paradox

Identifiers

PMID26056358
PMCPMC4581037

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.