ArticleHypertension (Dallas, Tex. : 1979)2015
Adiposity, obesity, and arterial aging: longitudinal study of aortic stiffness in the Whitehall II cohort.
Article in Hypertension (Dallas, Tex. : 1979), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 57 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
57 citing papers in PubMed, 109 citations in OpenAlex.
- Arterial Stiffening With Exercise in Patients With Heart Failure and Preserved Ejection Fraction.Journal of the American College of Cardiology · 2017Trial
- Twenty-Five-Year Alcohol Consumption Trajectories and Their Association With Arterial Aging: A Prospective Cohort Study.Journal of the American Heart Association · 2017Trial
- Regional cerebral arterial elasticity is associated with cardiovascular health in cognitively healthy older adults.bioRxiv : the preprint server for biology · 2026Article
- Evaluation of cardiovascular risk using smartwatch-measured pulse wave velocity in China: a nationwide cross-sectional study.Frontiers in cardiovascular medicine · 2026Article
- Analyzing the association of estimated pulse wave velocity with the risk and mortality of chronic kidney disease: a study based on the NHANES database.International urology and nephrology · 2026Article
- Arterial aging and the autonomic nervous system: is the relationship differently modified by physical activity in men and women?Frontiers in aging · 2025Article
- U-shaped Association Between Weight-Adjusted-Waist Index and Arterial Stiffness Among Adult Hypertensive Patients: A Population-Based Study in the United States.Journal of clinical hypertension (Greenwich, Conn.) · 2024Article
- Chinese visceral adipose index is more closely associated with risk of arterial stiffness than traditional obesity indicators: a cohort study.Diabetology & metabolic syndrome · 2024Article
- Discrepancies between general and central obesity in arterial stiffness: observational studies and Mendelian randomization study.BMC medicine · 2024Observational
- Article
- Association of organ damage with predicted fat mass in a community-dwelling elderly: the Northern Shanghai study.Aging clinical and experimental research · 2024Article
- Characteristics and Influencing Factors of Intra-Dialysis Blood Pressure Variability in Hemodialysis Patients: A Retrospective Study.International journal of general medicine · 2024Article
- Masked Hypertension in Healthy Children and Adolescents: Who Should Be Screened?Current hypertension reports · 2023Review
- Association between weight-adjusted waist index and arterial stiffness in hypertensive patients: The China H-type hypertension registry study.Frontiers in endocrinology · 2023Article
- Green Tea Polyphenols Prevent Early Vascular Aging Induced by High-Fat Diet via Promoting Autophagy in Young Adult Rats.Current medical science · 2022Article
- Correlation among Waist Circumference and Central Measures of Blood Pressure.Arquivos brasileiros de cardiologia · 2022Observational
- The Mediation Role of Fatness in Associations between Cardiorespiratory Fitness and Blood Pressure after High-Intensity Interval Training in Adolescents.International journal of environmental research and public health · 2022Article
- Does body mass index or waist-hip ratio correlate with arterial stiffness based on brachial-ankle pulse wave velocity in Chinese rural adults with hypertension?BMC cardiovascular disorders · 2021Article
- Effects of Exercise and Weight Loss on Proximal Aortic Stiffness in Older Adults With Obesity.Circulation · 2021Article
- Serum MMP-3 and its association with central arterial stiffness among young adults is moderated by smoking and BMI.Physiological reports · 2021Article
Corrections and comments
- Commented on by
- Erratum issuedCorrection.2015
Authors and funding
9 authors at 1 institution in 2 countries.
Funding
Abstract
We sought to determine whether adiposity in later midlife is an independent predictor of accelerated stiffening of the aorta. Whitehall II study participants (3789 men; 1383 women) underwent carotid-femoral applanation tonometry at the mean age of 66 and again 4 years later. General adiposity by body mass index, central adiposity by waist circumference and waist:hip ratio, and fat mass percent by body impedance were assessed 5 years before and at baseline. In linear mixed models adjusted for age, sex, ethnicity, and mean arterial pressure, all adiposity measures were associated with aortic stiffening measured as increase in pulse wave velocity (PWV) between baseline and follow-up. The associations were similar in the metabolically healthy and unhealthy, according to Adult Treatment Panel-III criteria excluding waist circumference. C-reactive protein and interleukin-6 levels accounted for part of the longitudinal association between adiposity and PWV change. Adjusting for chronic disease, antihypertensive medication and risk factors, standardized effects of general and central adiposity and fat mass percent on PWV increase (m/s) were similar (0.14, 95% confidence interval: 0.05-0.24, P=0.003; 0.17, 0.08-0.27, P<0.001; 0.14, 0.05-0.22, P=0.002, respectively). Previous adiposity was associated with aortic stiffening independent of change in adiposity, glycaemia, and lipid levels across PWV assessments. We estimated that the body mass index-linked PWV increase will account for 12% of the projected increase in cardiovascular risk because of high body mass index. General and central adiposity in later midlife were strong independent predictors of aortic stiffening. Our findings suggest that adiposity is an important and potentially modifiable determinant of arterial aging.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.