ArticleProceedings of the National Academy of Sciences of the United States of America2015
SAR11 lipid renovation in response to phosphate starvation.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed, 124 citations in OpenAlex.
- The phospholipase PlcP mediates membrane lipid remodeling required for the intracellular survival of Burkholderia cenocepacia.The Journal of biological chemistry · 2026Article
- Phosphoproteomics reveals essential regulatory roles of phosphorylation in marine oligotrophic bacteria.Marine life science & technology · 2026Article
- Phosphorus Acquisition Strategies Among Phytoplankton and Free-Living Bacterial Communities in the Baltic Proper.Environmental microbiology reports · 2026Article
- Exceptionally stable membrane lipid composition of the marine facultative anaerobe and piezotolerant 'Labilibaculum euxinus' under variable pressure and nutrients.FEMS microbiology ecology · 2026Article
- Phosphorus acquisition among planktonic microbial communities across a salinity gradient.ISME communications · 2026Article
- Unraveling plankton adaptation in global oceans through the untargeted analysis of lipidomes.Science advances · 2025Article
- Diel partitioning in microbial phosphorus acquisition in the Sargasso Sea.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Physiological and Transcriptional Responses to Phosphorus Deficiency and Glucose-6-Phosphate Supplementation inInternational journal of molecular sciences · 2024Article
- Nitrogen and sulfur for phosphorus: Lipidome adaptation of anaerobic sulfate-reducing bacteria in phosphorus-deprived conditions.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Organic matter degradation in the deep, sulfidic waters of the Black Sea: insights into the ecophysiology of novel anaerobic bacteria.Microbiome · 2024Article
- Autochthonous psychrophilic hydrocarbonoclastic bacteria and its ecological function in contaminated cold environments.Biodegradation · 2024Review
- Aminolipids in bacterial membranes and the natural environment.The ISME journal · 2024Review
- High-throughput metabarcoding of SAR11 assemblages from the southwest Atlantic shelf and arid Patagonia: richness and associated rank abundance distributions.Quantitative biology (Beijing, China) · 2023Article
- Bacterial lipid biophysics and membrane organization.Current opinion in microbiology · 2023Review
- Bacterial catabolism of membrane phospholipids links marine biogeochemical cycles.Science advances · 2023Article
- Intact polar lipidome and membrane adaptations of microbial communities inhabiting serpentinite-hosted fluids.Frontiers in microbiology · 2023Article
- Growth Substrate and Prophage Induction Collectively Influence Metabolite and Lipid Profiles in a Marine Bacterium.mSystems · 2022Article
- Trade-offs of lipid remodeling in a marine predator-prey interaction in response to phosphorus limitation.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- The Proteobacterial MethanotrophmBio · 2022Article
- Impact of phosphate concentration on the metabolome of biofilms of the marine bacterium Pseudoalteromonas lipolytica.Metabolomics : Official journal of the Metabolomic Society · 2022Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Phytoplankton inhabiting oligotrophic ocean gyres actively reduce their phosphorus demand by replacing polar membrane phospholipids with those lacking phosphorus. Although the synthesis of nonphosphorus lipids is well documented in some heterotrophic bacterial lineages, phosphorus-free lipid synthesis in oligotrophic marine chemoheterotrophs has not been directly demonstrated, implying they are disadvantaged in phosphate-deplete ecosystems, relative to phytoplankton. Here, we show the SAR11 clade chemoheterotroph Pelagibacter sp. str. HTCC7211 renovates membrane lipids when phosphate starved by replacing a portion of its phospholipids with monoglucosyl- and glucuronosyl-diacylglycerols and by synthesizing new ornithine lipids. Lipid profiles of cells grown with excess phosphate consisted entirely of phospholipids. Conversely, up to 40% of the total lipids were converted to nonphosphorus lipids when cells were starved for phosphate, or when growing on methylphosphonate. Cells sequentially limited by phosphate and methylphosphonate transformed >75% of their lipids to phosphorus-free analogs. During phosphate starvation, a four-gene cluster was significantly up-regulated that likely encodes the enzymes responsible for lipid renovation. These genes were found in Pelagibacterales strains isolated from a phosphate-deficient ocean gyre, but not in other strains from coastal environments, suggesting alternate lipid synthesis is a specific adaptation to phosphate scarcity. Similar gene clusters are found in the genomes of other marine α-proteobacteria, implying lipid renovation is a common strategy used by heterotrophic cells to reduce their requirement for phosphorus in oligotrophic habitats.
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