Evidence map›Paper›PMID 26056252›Full record

Observational studyCirculation research2015

Determinants and Outcomes of Accelerated Arteriosclerosis: Major Impact of Circulating Antibodies.

Alexandre Loupy, Dewi Vernerey, Denis Viglietti, Olivier Aubert, Jean-Paul Duong Van Huyen, Jean-Philippe Empana, Patrick Bruneval, Denis Glotz, Christophe Legendre, Xavier Jouven and 1 more

Open access · bronzeAbstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in Circulation research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
4.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 53 citations in OpenAlex.

  1. Review
  2. Article
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  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Proceedings of the 2024 Transplant AI Symposium.Frontiers in transplantation · 2024
    Article
  12. The evolving use of biomarkers in heart transplantation: Consensus of an expert panel.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2023
    Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Antibody-induced vascular inflammation skews infiltrating macrophages to a novel remodeling phenotype in a model of transplant rejection.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2020
    Article
  19. CirculatingFrontiers in pediatrics · 2020
    Article
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Alexandre LoupyFrom the Paris Translational Research Center for Organ Transplantation and Cardiovascular Disease, INSERM, UMR-S970, Paris, France (A.L., D. Viglietti, O.A., J.-P.D.V.H., J.-P.E., P.B., D.G., C. Legendre, X.J., C. Lefaucheur); Paris Descartes University, Sorbonne Paris Cité and Necker Hospital (A.L., J.-P.D.V.H., C. Legendre) and Department of Transplantation, Saint-Louis Hospital (D. Viglietti, D.G., C. Lefaucheur), Assistance Publique - Hôpitaux de Paris, Paris, France; Methodology Unit (EA 3181) CHRU de Besançon, Besançon, France (D. Vernerey); Department of Pathology, Necker Hospital, Paris, France (J.-P.D.V.H.); and Department of Pathology (P.B.) and Department of Cardiology (X.J.), Georges Pompidou European Hospital, Paris, France. alexandreloupy@gmail.com.
Dewi VernereyFrom the Paris Translational Research Center for Organ Transplantation and Cardiovascular Disease, INSERM, UMR-S970, Paris, France (A.L., D. Viglietti, O.A., J.-P.D.V.H., J.-P.E., P.B., D.G., C. Legendre, X.J., C. Lefaucheur); Paris Descartes University, Sorbonne Paris Cité and Necker Hospital (A.L., J.-P.D.V.H., C. Legendre) and Department of Transplantation, Saint-Louis Hospital (D. Viglietti, D.G., C. Lefaucheur), Assistance Publique - Hôpitaux de Paris, Paris, France; Methodology Unit (EA 3181) CHRU de Besançon, Besançon, France (D. Vernerey); Department of Pathology, Necker Hospital, Paris, France (J.-P.D.V.H.); and Department of Pathology (P.B.) and Department of Cardiology (X.J.), Georges Pompidou European Hospital, Paris, France.
Denis VigliettiFrom the Paris Translational Research Center for Organ Transplantation and Cardiovascular Disease, INSERM, UMR-S970, Paris, France (A.L., D. Viglietti, O.A., J.-P.D.V.H., J.-P.E., P.B., D.G., C. Legendre, X.J., C. Lefaucheur); Paris Descartes University, Sorbonne Paris Cité and Necker Hospital (A.L., J.-P.D.V.H., C. Legendre) and Department of Transplantation, Saint-Louis Hospital (D. Viglietti, D.G., C. Lefaucheur), Assistance Publique - Hôpitaux de Paris, Paris, France; Methodology Unit (EA 3181) CHRU de Besançon, Besançon, France (D. Vernerey); Department of Pathology, Necker Hospital, Paris, France (J.-P.D.V.H.); and Department of Pathology (P.B.) and Department of Cardiology (X.J.), Georges Pompidou European Hospital, Paris, France.
Olivier AubertFrom the Paris Translational Research Center for Organ Transplantation and Cardiovascular Disease, INSERM, UMR-S970, Paris, France (A.L., D. Viglietti, O.A., J.-P.D.V.H., J.-P.E., P.B., D.G., C. Legendre, X.J., C. Lefaucheur); Paris Descartes University, Sorbonne Paris Cité and Necker Hospital (A.L., J.-P.D.V.H., C. Legendre) and Department of Transplantation, Saint-Louis Hospital (D. Viglietti, D.G., C. Lefaucheur), Assistance Publique - Hôpitaux de Paris, Paris, France; Methodology Unit (EA 3181) CHRU de Besançon, Besançon, France (D. Vernerey); Department of Pathology, Necker Hospital, Paris, France (J.-P.D.V.H.); and Department of Pathology (P.B.) and Department of Cardiology (X.J.), Georges Pompidou European Hospital, Paris, France.
Jean-Paul Duong Van HuyenFrom the Paris Translational Research Center for Organ Transplantation and Cardiovascular Disease, INSERM, UMR-S970, Paris, France (A.L., D. Viglietti, O.A., J.-P.D.V.H., J.-P.E., P.B., D.G., C. Legendre, X.J., C. Lefaucheur); Paris Descartes University, Sorbonne Paris Cité and Necker Hospital (A.L., J.-P.D.V.H., C. Legendre) and Department of Transplantation, Saint-Louis Hospital (D. Viglietti, D.G., C. Lefaucheur), Assistance Publique - Hôpitaux de Paris, Paris, France; Methodology Unit (EA 3181) CHRU de Besançon, Besançon, France (D. Vernerey); Department of Pathology, Necker Hospital, Paris, France (J.-P.D.V.H.); and Department of Pathology (P.B.) and Department of Cardiology (X.J.), Georges Pompidou European Hospital, Paris, France.
Jean-Philippe EmpanaFrom the Paris Translational Research Center for Organ Transplantation and Cardiovascular Disease, INSERM, UMR-S970, Paris, France (A.L., D. Viglietti, O.A., J.-P.D.V.H., J.-P.E., P.B., D.G., C. Legendre, X.J., C. Lefaucheur); Paris Descartes University, Sorbonne Paris Cité and Necker Hospital (A.L., J.-P.D.V.H., C. Legendre) and Department of Transplantation, Saint-Louis Hospital (D. Viglietti, D.G., C. Lefaucheur), Assistance Publique - Hôpitaux de Paris, Paris, France; Methodology Unit (EA 3181) CHRU de Besançon, Besançon, France (D. Vernerey); Department of Pathology, Necker Hospital, Paris, France (J.-P.D.V.H.); and Department of Pathology (P.B.) and Department of Cardiology (X.J.), Georges Pompidou European Hospital, Paris, France.
Patrick BrunevalFrom the Paris Translational Research Center for Organ Transplantation and Cardiovascular Disease, INSERM, UMR-S970, Paris, France (A.L., D. Viglietti, O.A., J.-P.D.V.H., J.-P.E., P.B., D.G., C. Legendre, X.J., C. Lefaucheur); Paris Descartes University, Sorbonne Paris Cité and Necker Hospital (A.L., J.-P.D.V.H., C. Legendre) and Department of Transplantation, Saint-Louis Hospital (D. Viglietti, D.G., C. Lefaucheur), Assistance Publique - Hôpitaux de Paris, Paris, France; Methodology Unit (EA 3181) CHRU de Besançon, Besançon, France (D. Vernerey); Department of Pathology, Necker Hospital, Paris, France (J.-P.D.V.H.); and Department of Pathology (P.B.) and Department of Cardiology (X.J.), Georges Pompidou European Hospital, Paris, France.
Denis GlotzFrom the Paris Translational Research Center for Organ Transplantation and Cardiovascular Disease, INSERM, UMR-S970, Paris, France (A.L., D. Viglietti, O.A., J.-P.D.V.H., J.-P.E., P.B., D.G., C. Legendre, X.J., C. Lefaucheur); Paris Descartes University, Sorbonne Paris Cité and Necker Hospital (A.L., J.-P.D.V.H., C. Legendre) and Department of Transplantation, Saint-Louis Hospital (D. Viglietti, D.G., C. Lefaucheur), Assistance Publique - Hôpitaux de Paris, Paris, France; Methodology Unit (EA 3181) CHRU de Besançon, Besançon, France (D. Vernerey); Department of Pathology, Necker Hospital, Paris, France (J.-P.D.V.H.); and Department of Pathology (P.B.) and Department of Cardiology (X.J.), Georges Pompidou European Hospital, Paris, France.
Christophe LegendreFrom the Paris Translational Research Center for Organ Transplantation and Cardiovascular Disease, INSERM, UMR-S970, Paris, France (A.L., D. Viglietti, O.A., J.-P.D.V.H., J.-P.E., P.B., D.G., C. Legendre, X.J., C. Lefaucheur); Paris Descartes University, Sorbonne Paris Cité and Necker Hospital (A.L., J.-P.D.V.H., C. Legendre) and Department of Transplantation, Saint-Louis Hospital (D. Viglietti, D.G., C. Lefaucheur), Assistance Publique - Hôpitaux de Paris, Paris, France; Methodology Unit (EA 3181) CHRU de Besançon, Besançon, France (D. Vernerey); Department of Pathology, Necker Hospital, Paris, France (J.-P.D.V.H.); and Department of Pathology (P.B.) and Department of Cardiology (X.J.), Georges Pompidou European Hospital, Paris, France.
Xavier JouvenFrom the Paris Translational Research Center for Organ Transplantation and Cardiovascular Disease, INSERM, UMR-S970, Paris, France (A.L., D. Viglietti, O.A., J.-P.D.V.H., J.-P.E., P.B., D.G., C. Legendre, X.J., C. Lefaucheur); Paris Descartes University, Sorbonne Paris Cité and Necker Hospital (A.L., J.-P.D.V.H., C. Legendre) and Department of Transplantation, Saint-Louis Hospital (D. Viglietti, D.G., C. Lefaucheur), Assistance Publique - Hôpitaux de Paris, Paris, France; Methodology Unit (EA 3181) CHRU de Besançon, Besançon, France (D. Vernerey); Department of Pathology, Necker Hospital, Paris, France (J.-P.D.V.H.); and Department of Pathology (P.B.) and Department of Cardiology (X.J.), Georges Pompidou European Hospital, Paris, France.
Carmen LefaucheurFrom the Paris Translational Research Center for Organ Transplantation and Cardiovascular Disease, INSERM, UMR-S970, Paris, France (A.L., D. Viglietti, O.A., J.-P.D.V.H., J.-P.E., P.B., D.G., C. Legendre, X.J., C. Lefaucheur); Paris Descartes University, Sorbonne Paris Cité and Necker Hospital (A.L., J.-P.D.V.H., C. Legendre) and Department of Transplantation, Saint-Louis Hospital (D. Viglietti, D.G., C. Lefaucheur), Assistance Publique - Hôpitaux de Paris, Paris, France; Methodology Unit (EA 3181) CHRU de Besançon, Besançon, France (D. Vernerey); Department of Pathology, Necker Hospital, Paris, France (J.-P.D.V.H.); and Department of Pathology (P.B.) and Department of Cardiology (X.J.), Georges Pompidou European Hospital, Paris, France.
Hôpital Necker-Enfants Malades · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

rationaleThe role of circulating antibodies in addition to traditional cardiovascular risk factors in the development of accelerated arteriosclerosis and their long-term clinical consequences have not been demonstrated.

objectiveWe investigated the role of circulating antibodies in accelerated arteriosclerosis and the role of immune-associated arteriosclerosis in graft and patient survival and the occurrence of major adverse cardiovascular events. METHODS AND

resultsThis was an observational prospective cohort study that included 1065 kidney transplant patients (principal cohort, n=744; validation cohort, n=321) between 2004 and 2010. Participants were assessed for traditional cardiovascular risk factors and circulating anti-human leukocyte antigen (HLA) antibodies. All patients underwent allograft biopsies to assess arteriosclerotic lesions and endothelial activation, endarteritis, and complement deposition. In the principal cohort, 250 (33.6%) patients had severe arteriosclerosis (luminal narrowing >25% via fibrointimal arterial thickening). Circulating donor-specific anti-HLA antibodies were significantly associated with severe allograft arteriosclerosis (hazard ratio, 2.9; P<0.0001), independently of traditional risk factors. Patients with severe arteriosclerosis and anti-HLA antibodies (n=91, 12.2%) demonstrated allograft endothelial activation, endarteritis, and complement deposition. High levels of anti-HLA antibodies and their complement binding capacity were associated with increased severity of arteriosclerosis. Patients with antibody-associated severe arteriosclerosis had decreased allograft survival and increased mortality (P<0.0001); they exhibited a 2.5- and 4.1-fold increased risk of major adverse cardiovascular events compared with patients who had severe arteriosclerosis without antibodies and patients with minimal arteriosclerosis, respectively (P<0.0005). Circulating donor-specific anti-HLA antibodies were significantly associated with occurrence of major adverse cardiovascular events (hazard ratio, 2.4; P=0.0004), independently of traditional risk factors.

conclusionsCirculating antibodies are major determinants of severe arteriosclerosis and major adverse cardiovascular events, independent of traditional cardiovascular risk factors.

Indexed as

AdultAgedArteriosclerosisAutoantibodiesCohort StudiesFemaleFollow-Up StudiesGraft RejectionGraft SurvivalHLA AntigensHumansKidney TransplantationMaleMiddle AgedProspective StudiesTransplantation, HomologousAutoantibodiesHLA Antigensantibodiesarteriosclerosiscardiovascular diseasestransplantation

Identifiers

PMID26056252
OpenAlexW2106070337

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