ArticleThe Journal of experimental biology2015
Functional development of carbon dioxide detection in the maxillary palp of Anopheles gambiae.
Article in The Journal of experimental biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 62 citations in OpenAlex.
- Age-dependent perception of floral emissions and the role of COScientific reports · 2026Article
- Sensory coding of borneol repellency in culicine mosquitoes via the Or49 pathway.Nature communications · 2026Article
- Morphological specializations of mosquito COProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Differential sensitivity and specificity of Aedes aegypti and Anopheles gambiae to adenine nucleotide phagostimulants-an all-or-none response?Parasites & vectors · 2024Article
- An expanded neurogenetic toolkit to decode olfaction in the African malaria mosquito Anopheles gambiae.Cell reports methods · 2024Article
- Knockout of OR39 reveals redundancy in the olfactory pathway regulating the acquisition of host seeking inProceedings. Biological sciences · 2023Article
- Targeting Sex Determination to Suppress Mosquito Populations.Research square · 2023Article
- Mosquito host-seeking diel rhythm and chemosensory gene expression is affected by age and Plasmodium stages.Scientific reports · 2022Article
- Characterization ofInsects · 2021Article
- The Expression of Chemosensory Genes in Male Maxillary Palps of Anopheles coluzzii (Diptera: Culicidae) and An. quadriannulatus.Journal of medical entomology · 2021Article
- Regulation of the antennal transcriptome of the dengue vector, Aedes aegypti, during the first gonotrophic cycle.BMC genomics · 2021Article
- Modulation of odour-guided behaviour in mosquitoes.Cell and tissue research · 2021Review
- Mosquito Host Seeking in 3D Using a Versatile Climate-Controlled Wind Tunnel System.Frontiers in behavioral neuroscience · 2021Article
- The Malaria Metabolite HMBPP Does Not Trigger Erythrocyte Terpene Release.ACS infectious diseases · 2020Article
- Contributions of the Conserved Insect Carbon Dioxide Receptor Subunits to Odor Detection.Cell reports · 2020Article
- Evolution, developmental expression and function of odorant receptors in insects.The Journal of experimental biology · 2020Review
- Insect chemical ecology: chemically mediated interactions and novel applications in agriculture.Arthropod-plant interactions · 2020Article
- The Use of Granular Cyclopentanone as Alternative to Artificial Source of Carbon Dioxide in Improved Passive Outdoor Host Seeking Device (POHD).TheScientificWorldJournal · 2020Article
- CanPathogens and global health · 2019Review
- Age-dependent regulation of host seeking in Anopheles coluzzii.Scientific reports · 2019Article
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Authors and funding
3 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Olfactory information drives several behaviours critical for the survival and persistence of insect pests and vectors. Insect behaviour is variable, linked to their biological needs, and regulated by physiological dynamics. For mosquitoes, CO2 is an important cue that signifies the presence of a host, and which elicits activation and attraction. To investigate the genetic basis of olfactory modulation in mosquitoes, we assayed changes in CO2 detection from receptor gene expression through physiological function to behaviour, associated with the onset of host seeking in the malaria vector, Anopheles gambiae. The gene encoding a subunit of the CO2 receptor, AgGr22, was found to be significantly up-regulated in host-seeking females, consistent with a significant increase in sensitivity of CO2-responsive neurons (cpA) housed in capitate peg sensilla of the maxillary palp. In addition, the odorant receptor AgOr28, which is expressed in cpC neurons, was significantly up-regulated. In contrast, AgOr8, which is expressed in cpB neurons, was not affected by this change in physiological state, in agreement with results for the obligate co-receptor Orco. Moreover, the sensitivity of the cpB neuron to (R)-1-octen-3-ol, a well-known mammalian kairomone, did not change in response to the onset of host seeking. The concentration of CO2 flux influenced both the propensity of A. gambiae to take off into the wind and the speed with which this activation occurred. Female A. gambiae mosquitoes responded to CO2 whether mature for host seeking or not, but onset of host seeking enhanced sensitivity and speed of activation at relevant doses of CO2.
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