ArticleJournal of Zhejiang University. Science. B2015
Heat stress inhibits proliferation, promotes growth, and induces apoptosis in cultured Lantang swine skeletal muscle satellite cells.
Article in Journal of Zhejiang University. Science. B, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 53 citations in OpenAlex.
- RFLNA mitigates heat stress-impaired chondrocyte proliferation and vertebral development through cytoskeletal regulation in pigs.Journal of animal science and biotechnology · 2026Article
- Heat stress-induced gut dysbiosis and multi-organ injury: mechanisms and therapeutic modulation.Frontiers in cellular and infection microbiology · 2026Review
- Identification of single nucleotide polymorphisms (SNPs) associated with heat stress and milk production traits in Chinese holstein cows.BMC genomics · 2025Article
- Short-term heat exposure affects thermogenesis and mitophagy in goat brown adipocytes.BMC genomics · 2025Article
- Sodium Butyrate Alleviates Heat Stress-Induced Oxidative Stress and Skeletal Muscle Homeostasis Disruption by Promoting Autophagy in Mice.Nutrients · 2025Article
- Vitamin C Alleviates Heat-Stress-Induced Damages in Pig Thoracic Vertebral Chondrocytes via the Ubiquitin-Mediated Proteolysis Pathway.Antioxidants (Basel, Switzerland) · 2024Article
- Article
- Selenomethionine alleviates chronic heat stress-induced breast muscle injury and poor meat quality in broilers via relieving mitochondrial dysfunction and endoplasmic reticulum stress.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2024Article
- Article
- Identification of genes associated with abiotic stress tolerance in sweetpotato using weighted gene co-expression network analysis.Plant direct · 2023Article
- Heat shock protein 27 regulates myogenic and self-renewal potential of bovine satellite cells under heat stress.Journal of animal science · 2023Article
- Exposure to high thermal conditions for a long time induces apoptosis and decreases total RNA concentration in peripheral blood mononuclear cells among Indian Zebu-Jersey crossbreds.Veterinary world · 2022Article
- Morphological and Molecular Responses ofInternational journal of molecular sciences · 2022Article
- FeProgress in biomaterials · 2022Article
- The effects of temperature and donor piglet age on the transcriptomic profile and energy metabolism of myoblasts.Frontiers in physiology · 2022Article
- Extraordinarily rapid proliferation of cultured muscle satellite cells from migratory birds.Biology letters · 2021Article
- Effects of temperature on proliferation of myoblasts from donor piglets with different thermoregulatory maturities.BMC molecular and cell biology · 2021Article
- Direct exposure to mild heat stress stimulates cell viability and heat shock protein expression in primary cultured broiler fibroblasts.Cell stress & chaperones · 2020Article
- Heat induces myogenic transcription factors of myoblast cells via transient receptor potential vanilloid 1 (Trpv1).FEBS open bio · 2019Article
- Comparative study of the proliferative ability of skeletal muscle satellite cells under microwave irradiation in fractures with titanium alloy internal fixation in rabbits.Experimental and therapeutic medicine · 2018Article
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Proliferation suppression and apoptosis are the prominent characteristics induced by heat stress (HS) in cells, whereas the effects of HS on cell growth (mass accumulation) are unknown. In this study, Lantang swine (an indigenous breed of China) skeletal muscle satellite cells (SCs) were pre-cultured at 37 °C for 24 h. The HS group was subjected to HS at 41 °C, while the control group was maintained at 37 °C. Heat shock protein 70 (HSP70) expression and SC size are significantly increased (P<0.05) by HS, but cell proliferation is suppressed (P<0.05) and apoptosis is induced (P<0.05). HS led to a lower percentage of SCs in the G0/G1 phase (P<0.05) together with a higher percentage of SCs in the S phase (P<0.05). However, the percentage of SCs in the G2/M phase was decreased (P<0.05) at 48 h but then increased (P<0.05) at 72 h with HS. In addition, the phosphorylation ratios of protein kinase b (Akt), ribosomal protein S6 kinase (S6K), and ribosomal protein S6 were increased (P<0.05) by HS. Nevertheless, the phosphorylation ratios of the 4E binding protein 1 and the eukaryotic initiation factor-4E were indistinguishable (P>0.05) from those of the control group. The phosphorylation ratio of the mammalian target of rapamycin (mTOR) (Ser(2448)) increased (P<0.05) within 48 h, and apparent differences were abrogated at 72 h (P>0.05). Moreover, cleaved caspase-3 expression was increased at 72 h (P<0.05). These findings indicate that HS induces apoptosis and disrupts cell cycle distribution to decrease the number of cells. Additionally, HS can promote SC growth via an activated Akt/mTOR/S6K signaling pathway.
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