ReviewSleep medicine clinics2015
Melatonin Treatment in Children with Developmental Disabilities.
Review in Sleep medicine clinics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 64 citations in OpenAlex.
- Melatonin Use in Young Children: A Systematic Review.JAMA network open · 2026Pooled it
- Article
- Use of Basket Trials to Solve Sleep Problems in Patients with Rare Diseases.Clocks & sleep · 2024Article
- Incidence of Otolaryngological Manifestations in Individuals with Autism Spectrum Disorder: A Special Focus on Auditory Disorders.Audiology research · 2024Review
- Melatonin as a Chronobiotic with Sleep-promoting Properties.Current neuropharmacology · 2023Review
- Article
- Management of sleep disorders among children and adolescents with neurodevelopmental disorders: A practical guide for clinicians.World journal of clinical pediatrics · 2022Review
- Early Intervention for Children Aged 0 to 2 Years With or at High Risk of Cerebral Palsy: International Clinical Practice Guideline Based on Systematic Reviews.JAMA pediatrics · 2021Article
- Angelman syndrome and melatonin: What can they teach us about sleep regulation.Journal of pineal research · 2020Review
- Melatonin treatment of repetitive behavioral deficits in the Cntnap2 mouse model of autism spectrum disorder.Neurobiology of disease · 2020Article
- Efficacy and Safety of Melatonin Treatment in Children with Autism Spectrum Disorder and Attention-Deficit/Hyperactivity Disorder-A Review of the Literature.Brain sciences · 2020Review
- Sleep/Wake Disruption in a Mouse Model of BLOC-1 Deficiency.Frontiers in neuroscience · 2018Article
- Unmet clinical needs and burden in Angelman syndrome: a review of the literature.Orphanet journal of rare diseases · 2017Review
- Pharmacological therapies for Angelman syndrome.Wiener medizinische Wochenschrift (1946) · 2017Review
- Incontinence in persons with Angelman syndrome.European journal of pediatrics · 2017Article
- Melatonin and Angelman Syndrome: Implications and Mathematical Model of Diurnal Secretion.International journal of endocrinology · 2017Article
- Sleep Complaints and the 24-h Melatonin Level in Individuals with Smith-Magenis Syndrome: Assessment for Effective Intervention.CNS neuroscience & therapeutics · 2016Article
- Melatonin as a Potential Agent in the Treatment of Sarcopenia.International journal of molecular sciences · 2016Review
- Sleep in Neurodevelopmental Disorders.International review of research in developmental disabilities · 2016Article
- Measurement in saliva from neurotypical adults of biomarkers pertinent to autism spectrum disorders.Future science OA · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Melatonin is commonly recommended to treat sleep problems in children with developmental disabilities. However, few studies document the efficacy and safety of melatonin in these populations. This article reviews recent studies of melatonin efficacy in developmental disabilities. Overall, short treatment trials were associated with a significant decrease in sleep onset latency time for each of the disorders reviewed, with 1 notable exception-tuberous sclerosis. Reported side effects were uncommon and mild. Across disorders, additional research is needed to draw disability-specific conclusions. However, studies to date provide positive support for future trials that include larger groups of children with specific disabilities/syndromes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.