Evidence map›Paper›PMID 26055847›Full record

Trial reportPediatrics2015

Prenatal Hemoglobin Levels and Early Cognitive and Motor Functions of One-Year-Old Children.

Michael O Mireku, Leslie L Davidson, Ghislain K Koura, Smaïla Ouédraogo, Michael J Boivin, Xu Xiong, Manfred M K Accrombessi, Achille Massougbodji, Michel Cot, Florence Bodeau-Livinec

Open access · greenAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Pediatrics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 4 pooled it
9.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 4 syntheses or guidelines pooled it, 66 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Trial
  6. Trial
  7. Trial
  8. Article
  9. Article
  10. Prenatal Hemoglobin Concentration and Long-Term Child Neurocognitive Development.The American journal of tropical medicine and hygiene · 2025
    Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Anemia in Pregnancy With CKD.Kidney international reports · 2024
    Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 10 institutions in 4 countries.

Michael O MirekuEcole des Hautes Etudes en Santé Publique, Département Épidémiologie et Biostatistiques, Rennes, France; Université Pierre et Marie Curie (UPMC-Paris VI), Ecole doctorale Pierre Louis de santé publique, Paris, France; Institut de Recherche pour le Développement (IRD), Mère et Enfant Face aux Infections Tropicales, Paris, France; michael.osei.mireku@gmail.com.
Leslie L DavidsonMailman School of Public Health and the College of Physicians and Surgeons, Columbia University, New York, New York;
Ghislain K KouraUnion Internationale Contre la Tuberculose et les Maladies Respiratoires, Département Tuberculose et VIH, Paris, France;
Smaïla OuédraogoInstitut de Recherche pour le Développement (IRD), Mère et Enfant Face aux Infections Tropicales, Paris, France; Centre Hospitalier Universitaire Yalgado Ouédraogo, Ouagadougou, Burkina Faso;
Michael J BoivinDepartments of Psychiatry and Neurology/Ophthalmology, Michigan State University, East Lansing, Michigan;
Xu XiongDepartment of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana;
Manfred M K AccrombessiUniversité Pierre et Marie Curie (UPMC-Paris VI), Ecole doctorale Pierre Louis de santé publique, Paris, France; Institut de Recherche pour le Développement (IRD), Mère et Enfant Face aux Infections Tropicales, Paris, France;
Achille MassougbodjiUniversité d'Abomey-Calavi, Faculté des Sciences de la Santé, Cotonou, Bénin;
Michel CotInstitut de Recherche pour le Développement (IRD), Mère et Enfant Face aux Infections Tropicales, Paris, France; PRES Sorbonne Paris Cité, Université Paris Descartes, Faculté des Sciences Pharmaceutiques et Biologiques, Paris, France;
Florence Bodeau-LivinecEcole des Hautes Etudes en Santé Publique, Département Épidémiologie et Biostatistiques, Rennes, France; Center for Epidemiology and Statistics Sorbonne Paris Cité, Inserm UMR 1153, Obstetrical, Perinatal and Pediatric Epidemiology Research Team (Epopé), DHU Risks in Pregnancy, Paris Descartes University, Paris, France; and Division of Parasitology, Department of Microbiology, New York University Medical Center, New York, New York.
Centre Hospitalier Universitaire Yalgado Ouédraogo · BFColumbia University · USÉcole des Hautes Études en Santé Publique · FRInserm · FRInternational Union Against Tuberculosis and Lung Disease · FRMichigan State University · USSorbonne Paris Cité · FRSorbonne Université · FRTulane University · USUniversité d'Abomey-Calavi · BJ

Funding

Relationship between Periodontal Disease and Gestational Diabetes MellitusR21DE017764 · NIDCR · TULANE UNIVERSITY OF LOUISIANA · PI XIONG, XU · 2007 to 2008
$422k
Anemia in pregnancy in Benin and impact on cognitive function in childhoodR21HD060524 · NICHD · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI BODEAU-LIVINEC, FLORENCE · 2010 to 2011
$336k
NICHD NIH HHS R21 HD060524NICHD NIH HHS R21-HD060524NIDCR NIH HHS R21 DE017764
6 · The paper itself

Abstract

objectiveTo explore the relationship between prenatal hemoglobin (Hb) concentration and infant cognitive and motor functions.

methodsOur prospective cohort study included 1-year-old children born to women enrolled at their first antenatal care (ANC) visit in Allada, Benin, before 29 weeks of pregnancy, within a trial comparing the efficacy of sulfadoxine-pyrimethamine and mefloquine. Hb concentrations of pregnant women were determined from venous blood samples collected at first and second ANC visits of at least 1-month interval and at delivery. Women were prescribed oral iron, folic acid, and anthelminthics after the first ANC visit. A total of 636 children (76.8% of eligible children) were assessed by trained research nurses for cognitive and motor functions by using the Mullen Scales of Early Learning.

resultsPrevalence of anemia (Hb < 110 g/L) decreased from 67.0% at first ANC visit (mean gestational age [SD], 22.1 [4.0] weeks) to 38.4% at delivery. Mean (SD) Hb concentrations increased from 103.7 (12.3) at first ANC visit to 112.4 (14.1) at delivery. We observed a significant negative quadratic relationship between infant gross motor (GM) function and Hb concentration at first and second ANC visits. Thus, infant GM scores increased sharply with increasing maternal Hb concentration until 90 g/L where increasing GM was mild, and began to decline after 110 g/L.

conclusionsThere appears to be an Hb concentration range that may be optimal for GM function of 1-year-old children. This may reflect the importance of physiologic hemodilution, which occurs after the second trimester until 34 weeks of gestation.

Indexed as

Prenatal CareAnemiaBeninCognitionFemaleFollow-Up StudiesHemoglobinsHumansInfantInfant, NewbornMaleMotor ActivityPregnancyPrevalenceProspective StudiesHemoglobins

Identifiers

PMID26055847
PMCPMC9924076
OpenAlexW1939663417

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.