ArticleAmerican journal of physiology. Heart and circulatory physiology2015
Chronic endurance exercise affects paracrine action of CD31+ and CD34+ cells on endothelial tube formation.
Article in American journal of physiology. Heart and circulatory physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 30 citations in OpenAlex.
- The synergistic effects of saxagliptin and metformin on CD34+ endothelial progenitor cells in early type 2 diabetes patients: a randomized clinical trial.Cardiovascular diabetology · 2018Trial
- Mitochondria-specific antioxidant supplementation does not influence endurance exercise training-induced adaptations in circulating angiogenic cells, skeletal muscle oxidative capacity or maximal oxygen uptake.The Journal of physiology · 2016Trial
- Peripheral blood mononuclear cell number and paracrine function in responses to a 50-km trail race: An exploratory study.Physiological reports · 2025Article
- Effect of Cardiac Rehabilitation Program on Left Ventricular Systolic Function in Patients With Breast Cancer Receiving Anthracycline-based Chemotherapy Using Two-dimensional Speckle Tracking Echocardiography.Journal of the Saudi Heart Association · 2025Article
- Relevance of Cardiovascular Exercise in Cancer and Cancer Therapy-Related Cardiac Dysfunction.Current heart failure reports · 2024Review
- Aerobically trained older adults show impaired resting, but preserved exercise-induced circulating progenitor cell count, which was not improved by sprint interval training.Pflugers Archiv : European journal of physiology · 2023Article
- [Progress of pathogenesis and genetics of alcohol-induced osteonecrosis of femoral head].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2022Review
- Aerobic exercise-induced circulating extracellular vesicle combined decellularized dermal matrix hydrogel facilitates diabetic wound healing by promoting angiogenesis.Frontiers in bioengineering and biotechnology · 2022Article
- BM-MSC-derived small extracellular vesicles (sEV) from trained animals presented nephroprotective potential in unilateralureteral obstruction model.The journal of venomous animals and toxins including tropical diseases · 2021Article
- CD31+ Circulating Angiogenic Cell Number and Subtypes are Reduced in Individuals with Chronic Stroke.Current neurovascular research · 2021Article
- Sex-specific alterations in blood-borne factors in physically inactive individuals are detrimental to endothelial cell functions.Journal of applied physiology (Bethesda, Md. : 1985) · 2020Article
- Establishment of optimal exercise therapy using near-infrared spectroscopy monitoring of tissue muscle oxygenation after therapeutic angiogenesis for patients with critical limb ischemia: A multicenter, randomized, controlled trial.Contemporary clinical trials communications · 2020Article
- S100 Calcium Binding Protein A9 Represses Angiogenic Activity and Aggravates Osteonecrosis of the Femoral Head.International journal of molecular sciences · 2019Article
- Serum IL-6 and sIL-6R in type 2 diabetes contribute to impaired capillary-like network formation.Journal of applied physiology (Bethesda, Md. : 1985) · 2019Article
- Exercise and Cardiovascular Progenitor Cells.Comprehensive Physiology · 2019Review
- Identification of the key genes and long non‑coding RNAs in ankylosing spondylitis using RNA sequencing.International journal of molecular medicine · 2019Article
- Effects of CD100 promote wound healing in diabetic mice.Journal of molecular histology · 2018Article
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- Muscle Stem Cell and Physical Activity: What Point is the Debate at?Open medicine (Warsaw, Poland) · 2017Article
- Investigating the extremes of the continuum of paracrine functions in CD34-/CD31+ CACs across diverse populations.American journal of physiology. Heart and circulatory physiology · 2017Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
We aimed to determine if chronic endurance-exercise habits affected redox status and paracrine function of CD34(+) and CD34(-)/CD31(+) circulating angiogenic cells (CACs). Subjects were healthy, nonsmoking men and women aged 18-35 yr and categorized by chronic physical activity habits. Blood was drawn from each subject for isolation and culture of CD34(+) and CD34(-)/CD31(+) CACs. No differences in redox status were found in any group across either cell type. Conditioned media (CM) was generated from the cultured CACs and used in an in vitro human umbilical vein endothelial cell-based tube assay. CM from CD34(+) cells from inactive individuals resulted in tube structures that were 29% shorter in length (P < 0.05) and 45% less complex (P < 0.05) than the endurance-trained group. CD34(-)/CD31(+) CM from inactive subjects resulted in tube structures that were 26% shorter in length (P < 0.05) and 42% less complex (P < 0.05) than endurance-trained individuals. Proteomics analyses identified S100A8 and S100A9 in the CM. S100A9 levels were 103% higher (P < 0.05) and S100A8 was 97% higher in the CD34(-)/CD31(+) CM of inactive subjects compared with their endurance-trained counterparts with no significant differences in either protein in the CM of CD34(+) CACs as a function of training status. Recombinant S100A8/A9 treatment at concentrations detected in inactive subjects' CD34(-)/CD31(+) CAC CM also reduced tube formation (P < 0.05). These findings are the first, to our knowledge, to demonstrate a differential paracrine role in CD34(+) and CD34(-)/CD31(+) CACs on tube formation as a function of chronic physical activity habits and identifies a differential secretion of S100A9 by CD34(-)/CD31(+) CACs due to habitual exercise.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.