ReviewThe Journal of biological chemistry2015
Mycobacterium tuberculosis and Copper: A Newly Appreciated Defense against an Old Foe?
Review in The Journal of biological chemistry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed.
- VapC36-mediated intrinsic stress adaption is required for copper tolerance and pathogenesis ofScience advances · 2026Article
- Copper homeostasis in macrophages: regulatory mechanisms and immunological implications.Frontiers in chemistry · 2026Review
- Vitamin C potentiates the killing ofmBio · 2025Article
- Article
- Thiol, His-His Motif, and the Battle over Cu(II) in the Relationship of CopM Metallophore and OprC Outer Membrane Protein.Inorganic chemistry · 2025Article
- Testing the Antigenic Potential of Transmembrane Proteins To Develop a Thermostable Tuberculosis MOF-Liposomal Vaccine.ACS infectious diseases · 2025Article
- Copper homeostasis; A rapier between mycobacteria and macrophages.FASEB bioAdvances · 2025Review
- Exploring host-pathogen interactions in the Dictyostelium discoideum-Mycobacterium marinum infection model of tuberculosis.Disease models & mechanisms · 2024Review
- The role of transcriptional regulators in metal ion homeostasis ofFrontiers in cellular and infection microbiology · 2024Review
- MSMEG_0918 is not Essential for the Growth ofmicroPublication biology · 2024Article
- Identification of cuproptosis-related molecular subtypes as a biomarker for differentiating active from latent tuberculosis in children.BMC genomics · 2023Article
- The TbD1 Locus Mediates a Hypoxia-Induced Copper Response inFrontiers in microbiology · 2022Article
- Article
- Integrated sensing of host stresses by inhibition of a cytoplasmic two-component system controlseLife · 2021Article
- A Role forInternational journal of molecular sciences · 2021Article
- An improved statistical method to identify chemical-genetic interactions by exploiting concentration-dependence.PloS one · 2021Article
- Article
- The Role of Copper Homeostasis at the Host-Pathogen Axis: From Bacteria to Fungi.International journal of molecular sciences · 2019Review
- Bacterial copper storage proteins.The Journal of biological chemistry · 2018Review
- Introduction to Metals in Biology 2018: Copper homeostasis and utilization in redox enzymes.The Journal of biological chemistry · 2018Review
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
Several independent studies have recently converged upon the conclusion that the human bacterial pathogen Mycobacterium tuberculosis encounters copper during infections. At least three independently regulated pathways respond to excess copper and are required for the full virulence of M. tuberculosis in animals. In this review, I will discuss the functions of the best-characterized copper-responsive proteins in M. tuberculosis, the potential sources of copper during an infection, and remaining questions about the interface between copper and tuberculosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.