ArticleNature communications2015
Pharmacogenomic and clinical data link non-pharmacokinetic metabolic dysregulation to drug side effect pathogenesis.
Article in Nature communications, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 47 citations in OpenAlex.
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- Phenotypic similarity of adverse drug reactions and disease phenotypes is a bridge to mechanistic discovery.npj drug discovery · 2025Article
- What are side effects?European journal for philosophy of science · 2023Article
- QuTIE: quantum optimization for target identification by enzymes.Bioinformatics advances · 2023Article
- Genome-scale metabolic modeling in antimicrobial pharmacology.Engineering microbiology · 2022Review
- The Metano Modeling Toolbox MMTB: An Intuitive, Web-Based Toolbox Introduced by Two Use Cases.Metabolites · 2021Article
- A hexokinase isoenzyme switch in human liver cancer cells promotes lipogenesis and enhances innate immunity.Communications biology · 2021Article
- Genome-scale integration of transcriptome and metabolome unveils squalene synthase and dihydrofolate reductase as targets against AML cells resistant to chemotherapy.Computational and structural biotechnology journal · 2021Article
- FBA reveals guanylate kinase as a potential target for antiviral therapies against SARS-CoV-2.Bioinformatics (Oxford, England) · 2020Article
- Opportunities for Artificial Intelligence in Advancing Precision Medicine.Current genetic medicine reports · 2019Article
- Assessing key decisions for transcriptomic data integration in biochemical networks.PLoS computational biology · 2019Article
- Predicting gastrointestinal drug effects using contextualized metabolic models.PLoS computational biology · 2019Article
- Human Systems Biology and Metabolic Modelling: A Review-From Disease Metabolism to Precision Medicine.BioMed research international · 2019Review
- Integrated human-virus metabolic stoichiometric modelling predicts host-based antiviral targets against Chikungunya, Dengue and Zika viruses.Journal of the Royal Society, Interface · 2018Article
- Recon3D enables a three-dimensional view of gene variation in human metabolism.Nature biotechnology · 2018Article
- Predicting Dynamic Metabolic Demands in the Photosynthetic EukaryotePlant physiology · 2018Article
- Elucidation of complexity and prediction of interactions in microbial communities.Microbial biotechnology · 2017Review
- Analysis of free text in electronic health records for identification of cancer patient trajectories.Scientific reports · 2017Article
- Reconciled rat and human metabolic networks for comparative toxicogenomics and biomarker predictions.Nature communications · 2017Article
- Metabolic profiling of triple-negative breast cancer cells reveals metabolic vulnerabilities.Cancer & metabolism · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
Abstract
Drug side effects cause a significant clinical and economic burden. However, mechanisms of drug action underlying side effect pathogenesis remain largely unknown. Here, we integrate pharmacogenomic and clinical data with a human metabolic network and find that non-pharmacokinetic metabolic pathways dysregulated by drugs are linked to the development of side effects. We show such dysregulated metabolic pathways contain genes with sequence variants affecting side effect incidence, play established roles in pathophysiology, have significantly altered activity in corresponding diseases, are susceptible to metabolic inhibitors and are effective targets for therapeutic nutrient supplementation. Our results indicate that metabolic dysregulation represents a common mechanism underlying side effect pathogenesis that is distinct from the role of metabolism in drug clearance. We suggest that elucidating the relationships between the cellular response to drugs, genetic variation of patients and cell metabolism may help managing side effects by personalizing drug prescriptions and nutritional intervention strategies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.