ArticleCardiovascular diabetology2015
Protective role of oleic acid against cardiovascular insulin resistance and in the early and late cellular atherosclerotic process.
Article in Cardiovascular diabetology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
75 citing papers in PubMed, 1 synthesis or guideline pooled it, 160 citations in OpenAlex.
- Effect of Peanut Consumption on Cardiovascular Risk Factors: A Randomized Clinical Trial and Meta-Analysis.Frontiers in nutrition · 2022Pooled it
- Effects of Sacha Inchi (Plukenetia volubilis L.) Oil Supplementation on Hyperglycaemia, Hypertension and Hyperlipidaemia (3Hs) Patients: A Preliminary Human Trial.Plant foods for human nutrition (Dordrecht, Netherlands) · 2025Trial
- Docosahexaenoic acid enrichment in NAFLD is associated with improvements in hepatic metabolism and hepatic insulin sensitivity: a pilot study.European journal of clinical nutrition · 2017Trial
- Erythrocyte linoleic acid, but not oleic acid, is associated with improvements in body composition in men and women.Molecular nutrition & food research · 2016Trial
- Change in Association Between Minerals, Fatty Acids and Oxidative Stress Parameters in Wistar Rats with Different Diets.Animals : an open access journal from MDPI · 2026Article
- Valorization of Acorns Through the Development of Novel Plant-Based Products: Formulation and Shelf-Life Assessment.Foods (Basel, Switzerland) · 2026Article
- Oleic Acid Levels in HSAInternational journal of molecular sciences · 2026Article
- Hass Avocado Bioactive Compounds Attenuating Oxidative Stress and Inflammation in Ischemia-reperfusion Injury: An Integrative Review.Plant foods for human nutrition (Dordrecht, Netherlands) · 2026Review
- Antioxidant and antibacterial potential of bioactive extraction from Cadaba glandulosa leaves.PloS one · 2026Article
- Palmitic but Not Oleic Acid Induces Pro-Inflammatory Dysfunction of Human Endothelial Cells from Different Vascular Beds In Vitro.International journal of molecular sciences · 2025Article
- Impact of dietary patterns on pain and quality of life in ovarian and deep endometriosis: observational study for nutritional interventions.BMC women's health · 2025Observational
- Quantity of fat consumed predisposes cardiac tissues to greater metabolic risk than their level of saturation.Scientific reports · 2025Article
- Impact of olive oil and different animal fats on tissue lipid profiles of C57PL/6N mice fed non-atherogenic diet.Scientific reports · 2025Article
- Dietary oleic acid drives obesogenic adipogenesis via modulation of LXRα signaling.Cell reports · 2025Article
- Comparative analysis of lipid profiles and aroma characteristics in pecan oils: Probing conventional and non-conventional extraction techniques.Food chemistry: X · 2025Article
- Saturated fat in an evolutionary context.Lipids in health and disease · 2025Review
- Mechanisms of Bioactive Lipids to Modulate Master Regulators of Lipid Homeostasis and Inflammation in Metabolic Syndrome.Current pharmaceutical biotechnology · 2025Review
- The effects of saturated and unsaturated fatty acids on MASLD: a Mendelian randomization analysis and in vivo experiment.European journal of nutrition · 2024Article
- Effects of altering the ratio of C16:0 and cis-9 C18:1 in rumen bypass fat on growth performance, lipid metabolism, intestinal barrier, cecal microbiota, and inflammation in fattening bulls.Journal of animal science and biotechnology · 2024Article
- Antithrombotic Effect of Oil from the Pulp of Bocaiúva-Nutrients · 2024Article
15 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSeveral translational studies have identified the differential role between saturated and unsaturated fatty acids at cardiovascular level. However, the molecular mechanisms that support the protective role of oleate in cardiovascular cells are poorly known. For these reasons, we studied the protective role of oleate in the insulin resistance and in the atherosclerotic process at cellular level such as in cardiomyocytes (CMs), vascular smooth muscle cells (VSMCs) and endothelial cells (ECs).
methodsThe effect of oleate in the cardiovascular insulin resistance, vascular dysfunction, inflammation, proliferation and apoptosis of VSMCs were analyzed by Western blot, qRT-PCR, BrdU incorporation and cell cycle analysis.
resultsPalmitate induced insulin resistance. However, oleate not only did not induce cardiovascular insulin resistance but also had a protective effect against insulin resistance induced by palmitate or TNFα. One mechanism involved might be the prevention by oleate of JNK-1/2 or NF-κB activation in response to TNF-α or palmitate. Oleate reduced MCP-1 and ICAM-1 and increased eNOS expression induced by proinflammatory cytokines in ECs. Furthermore, oleate impaired the proliferation induced by TNF-α, angiotensin II or palmitate and the apoptosis induced by TNF-α or thapsigargin in VSMCs.
conclusionsOur data suggest a differential role between oleate and palmitate and support the concept of the cardioprotector role of oleate as the main lipid component of virgin olive oil. Thus, oleate protects against cardiovascular insulin resistance, improves endothelial dysfunction in response to proinflammatory signals and finally, reduces proliferation and apoptosis in VSMCs that may contribute to an ameliorated atherosclerotic process and plaque stability.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.